Novel rat Alzheimer's disease models based on AAV-mediated gene transfer to selectively increase hippocampal Aβ levels

Novel rat Alzheimer's disease models based on AAV-mediated gene transfer to selectively increase hippocampal Aβ levels

<p>Abstract</p> <p>Background</p> <p>Alzheimer's disease (AD) is characterized by a decline in cognitive function and accumulation of amyloid-β peptide (Aβ) in extracellular plaques. Mutations in amyloid precursor protein (APP) and presenilins alter APP metabolism...

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Bibliographic Details
Main Authors: Dicker Bridget L, Smithson Lisa, Holloway Vallie, Price Robert W, Das Pritam, Bland Ross J, Lawlor Patricia A, During Matthew J, Young Deborah, Golde Todd E
Format: Article
Language:English
Published: BMC 2007-06-01
Series:Molecular Neurodegeneration
Online Access:http://www.molecularneurodegeneration.com/content/2/1/11

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