Bone-Mimicking Injectable Gelatine/Hydroxyapatite Hydrogels

Bioactive synthetic hydrogels have emerged as promising materials because they can provide molecularly tailored biofunctions and adjustable mechanical properties. To mimic the mineralogical and organic components of the natural bone, hydroxyapatite and a tyramine conjugate of gelatine were combined...

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Main Authors:	A. Rogina, N. Šandrk, L. Teruel-Biosca, M. Antunović, M. Ivanković, G. Gallego Ferrer
Format:	Article
Language:	English
Published:	Croatian Society of Chemical Engineers 2019-10-01
Series:	Chemical and Biochemical Engineering Quarterly
Subjects:	gelatine hydroxyapatite injectable hydrogel rheology cytotoxicity
Online Access:	http://silverstripe.fkit.hr/cabeq/assets/Uploads/03-3-19.pdf

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spelling	doaj-646b63e3b3474178a2293331732d21312020-11-25T02:44:23ZengCroatian Society of Chemical EngineersChemical and Biochemical Engineering Quarterly0352-95681846-51532019-10-0133332533510.15255/CABEQ.2019.1663Bone-Mimicking Injectable Gelatine/Hydroxyapatite HydrogelsA. Rogina0N. Šandrk1L. Teruel-Biosca2M. Antunović3M. Ivanković4G. Gallego Ferrer5Faculty of Chemical Engineering and Technology, University of Zagreb, HR-10001 Zagreb, Marulićev trg 19, p.p.177, CroatiaFaculty of Chemical Engineering and Technology, University of Zagreb, HR-10001 Zagreb, Marulićev trg 19, p.p.177, CroatiaCentre for Biomaterials and Tissue Engineering, Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, SpainFaculty of Chemical Engineering and Technology, University of Zagreb, HR-10001 Zagreb, Marulićev trg 19, p.p.177, CroatiaFaculty of Chemical Engineering and Technology, University of Zagreb, HR-10001 Zagreb, Marulićev trg 19, p.p.177, Croatiab)Centre for Biomaterials and Tissue Engineering, Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, Spain; c)Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Mariano Esquillor s/n, 50018 Zaragoza, SpainBioactive synthetic hydrogels have emerged as promising materials because they can provide molecularly tailored biofunctions and adjustable mechanical properties. To mimic the mineralogical and organic components of the natural bone, hydroxyapatite and a tyramine conjugate of gelatine were combined in this study. The effect of various amounts of in situ synthesized hydroxyapatite in gelatine-tyramine on the morphology and physical properties of injectable hydrogels was investigated. Mineralogical identification confirmed successful precipitation of in situ formed hydroxyapatite. Better distribution of hydroxyapatite crystal agglomerates within modified gelatine was found at 5 % of hydroxyapatite, which could be responsible for increased storage modulus with respect to pure gelatine hydrogel. Prepared composite hydrogels are non-toxic and support the proliferation of Hek293 cells.http://silverstripe.fkit.hr/cabeq/assets/Uploads/03-3-19.pdfgelatinehydroxyapatiteinjectablehydrogelrheologycytotoxicity
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	A. Rogina N. Šandrk L. Teruel-Biosca M. Antunović M. Ivanković G. Gallego Ferrer
spellingShingle	A. Rogina N. Šandrk L. Teruel-Biosca M. Antunović M. Ivanković G. Gallego Ferrer Bone-Mimicking Injectable Gelatine/Hydroxyapatite Hydrogels Chemical and Biochemical Engineering Quarterly gelatine hydroxyapatite injectable hydrogel rheology cytotoxicity
author_facet	A. Rogina N. Šandrk L. Teruel-Biosca M. Antunović M. Ivanković G. Gallego Ferrer
author_sort	A. Rogina
title	Bone-Mimicking Injectable Gelatine/Hydroxyapatite Hydrogels
title_short	Bone-Mimicking Injectable Gelatine/Hydroxyapatite Hydrogels
title_full	Bone-Mimicking Injectable Gelatine/Hydroxyapatite Hydrogels
title_fullStr	Bone-Mimicking Injectable Gelatine/Hydroxyapatite Hydrogels
title_full_unstemmed	Bone-Mimicking Injectable Gelatine/Hydroxyapatite Hydrogels
title_sort	bone-mimicking injectable gelatine/hydroxyapatite hydrogels
publisher	Croatian Society of Chemical Engineers
series	Chemical and Biochemical Engineering Quarterly
issn	0352-9568 1846-5153
publishDate	2019-10-01
description	Bioactive synthetic hydrogels have emerged as promising materials because they can provide molecularly tailored biofunctions and adjustable mechanical properties. To mimic the mineralogical and organic components of the natural bone, hydroxyapatite and a tyramine conjugate of gelatine were combined in this study. The effect of various amounts of in situ synthesized hydroxyapatite in gelatine-tyramine on the morphology and physical properties of injectable hydrogels was investigated. Mineralogical identification confirmed successful precipitation of in situ formed hydroxyapatite. Better distribution of hydroxyapatite crystal agglomerates within modified gelatine was found at 5 % of hydroxyapatite, which could be responsible for increased storage modulus with respect to pure gelatine hydrogel. Prepared composite hydrogels are non-toxic and support the proliferation of Hek293 cells.
topic	gelatine hydroxyapatite injectable hydrogel rheology cytotoxicity
url	http://silverstripe.fkit.hr/cabeq/assets/Uploads/03-3-19.pdf
work_keys_str_mv	AT arogina bonemimickinginjectablegelatinehydroxyapatitehydrogels AT nsandrk bonemimickinginjectablegelatinehydroxyapatitehydrogels AT lteruelbiosca bonemimickinginjectablegelatinehydroxyapatitehydrogels AT mantunovic bonemimickinginjectablegelatinehydroxyapatitehydrogels AT mivankovic bonemimickinginjectablegelatinehydroxyapatitehydrogels AT ggallegoferrer bonemimickinginjectablegelatinehydroxyapatitehydrogels
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Bone-Mimicking Injectable Gelatine/Hydroxyapatite Hydrogels

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