Combined model of intrinsic and extrinsic variability for computational network design with application to synthetic biology.

Biological systems are inherently variable, with their dynamics influenced by intrinsic and extrinsic sources. These systems are often only partially characterized, with large uncertainties about specific sources of extrinsic variability and biochemical properties. Moreover, it is not yet well under...

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Bibliographic Details
Main Authors: Tina Toni, Bruce Tidor
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC3610654?pdf=render