Inferring multilayer interactome networks shaping phenotypic plasticity and evolution

Inferring multilayer interactome networks shaping phenotypic plasticity and evolution

Genetic plasticity drives phenotypic differences. Here, the authors develop a framework to quantify the individual and combinatorial contributions of SNPs on a phenotype of interest and use it to identify SNP-SNP interactions associated with variations in bacteria’s response to external changes.

Bibliographic Details
Main Authors: Dengcheng Yang, Yi Jin, Xiaoqing He, Ang Dong, Jing Wang, Rongling Wu
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25086-5
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spelling doaj-6469cecdafd94ea58b6bbbc6fab63a442021-09-12T11:45:09ZengNature Publishing GroupNature Communications2041-17232021-09-0112111710.1038/s41467-021-25086-5Inferring multilayer interactome networks shaping phenotypic plasticity and evolutionDengcheng Yang0Yi Jin1Xiaoqing He2Ang Dong3Jing Wang4Rongling Wu5Beijing Advanced Innovation Center for Tree Breeding by Molecular Design, Beijing Forestry UniversityBeijing Advanced Innovation Center for Tree Breeding by Molecular Design, Beijing Forestry UniversityBeijing Advanced Innovation Center for Tree Breeding by Molecular Design, Beijing Forestry UniversityBeijing Advanced Innovation Center for Tree Breeding by Molecular Design, Beijing Forestry UniversityBeijing Advanced Innovation Center for Tree Breeding by Molecular Design, Beijing Forestry UniversityBeijing Advanced Innovation Center for Tree Breeding by Molecular Design, Beijing Forestry UniversityGenetic plasticity drives phenotypic differences. Here, the authors develop a framework to quantify the individual and combinatorial contributions of SNPs on a phenotype of interest and use it to identify SNP-SNP interactions associated with variations in bacteria’s response to external changes.https://doi.org/10.1038/s41467-021-25086-5
collection DOAJ
language English
format Article
sources DOAJ
author Dengcheng Yang
Yi Jin
Xiaoqing He
Ang Dong
Jing Wang
Rongling Wu
spellingShingle Dengcheng Yang
Yi Jin
Xiaoqing He
Ang Dong
Jing Wang
Rongling Wu
Inferring multilayer interactome networks shaping phenotypic plasticity and evolution
Nature Communications
author_facet Dengcheng Yang
Yi Jin
Xiaoqing He
Ang Dong
Jing Wang
Rongling Wu
author_sort Dengcheng Yang
title Inferring multilayer interactome networks shaping phenotypic plasticity and evolution
title_short Inferring multilayer interactome networks shaping phenotypic plasticity and evolution
title_full Inferring multilayer interactome networks shaping phenotypic plasticity and evolution
title_fullStr Inferring multilayer interactome networks shaping phenotypic plasticity and evolution
title_full_unstemmed Inferring multilayer interactome networks shaping phenotypic plasticity and evolution
title_sort inferring multilayer interactome networks shaping phenotypic plasticity and evolution
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-09-01
description Genetic plasticity drives phenotypic differences. Here, the authors develop a framework to quantify the individual and combinatorial contributions of SNPs on a phenotype of interest and use it to identify SNP-SNP interactions associated with variations in bacteria’s response to external changes.
url https://doi.org/10.1038/s41467-021-25086-5
work_keys_str_mv AT dengchengyang inferringmultilayerinteractomenetworksshapingphenotypicplasticityandevolution
AT yijin inferringmultilayerinteractomenetworksshapingphenotypicplasticityandevolution
AT xiaoqinghe inferringmultilayerinteractomenetworksshapingphenotypicplasticityandevolution
AT angdong inferringmultilayerinteractomenetworksshapingphenotypicplasticityandevolution
AT jingwang inferringmultilayerinteractomenetworksshapingphenotypicplasticityandevolution
AT ronglingwu inferringmultilayerinteractomenetworksshapingphenotypicplasticityandevolution
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