Germline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burden

Germline variants that affect the expression or function of protein-coding regions of cancer genes are associated with cancer susceptibility. Here, the authors show that a larger number of germline variants are present in early-onset cancers, while acquired somatic mutations are prevalent in cancers...

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Main Authors:	Tao Qing, Hussein Mohsen, Michal Marczyk, Yixuan Ye, Tess O’Meara, Hongyu Zhao, Jeffrey P. Townsend, Mark Gerstein, Christos Hatzis, Yuval Kluger, Lajos Pusztai
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-16293-7

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spelling	doaj-6465db3a292f40d4a8d14f8e7096e4312021-05-16T11:11:32ZengNature Publishing GroupNature Communications2041-17232020-05-011111810.1038/s41467-020-16293-7Germline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burdenTao Qing0Hussein Mohsen1Michal Marczyk2Yixuan Ye3Tess O’Meara4Hongyu Zhao5Jeffrey P. Townsend6Mark Gerstein7Christos Hatzis8Yuval Kluger9Lajos Pusztai10Breast Medical Oncology, School of Medicine, Yale UniversityComputational Biology and Bioinformatics Program, Yale UniversityBreast Medical Oncology, School of Medicine, Yale UniversityComputational Biology and Bioinformatics Program, Yale UniversityBreast Medical Oncology, School of Medicine, Yale UniversityComputational Biology and Bioinformatics Program, Yale UniversityComputational Biology and Bioinformatics Program, Yale UniversityComputational Biology and Bioinformatics Program, Yale UniversityBreast Medical Oncology, School of Medicine, Yale UniversityComputational Biology and Bioinformatics Program, Yale UniversityBreast Medical Oncology, School of Medicine, Yale UniversityGermline variants that affect the expression or function of protein-coding regions of cancer genes are associated with cancer susceptibility. Here, the authors show that a larger number of germline variants are present in early-onset cancers, while acquired somatic mutations are prevalent in cancers that develop at older age.https://doi.org/10.1038/s41467-020-16293-7
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Tao Qing Hussein Mohsen Michal Marczyk Yixuan Ye Tess O’Meara Hongyu Zhao Jeffrey P. Townsend Mark Gerstein Christos Hatzis Yuval Kluger Lajos Pusztai
spellingShingle	Tao Qing Hussein Mohsen Michal Marczyk Yixuan Ye Tess O’Meara Hongyu Zhao Jeffrey P. Townsend Mark Gerstein Christos Hatzis Yuval Kluger Lajos Pusztai Germline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burden Nature Communications
author_facet	Tao Qing Hussein Mohsen Michal Marczyk Yixuan Ye Tess O’Meara Hongyu Zhao Jeffrey P. Townsend Mark Gerstein Christos Hatzis Yuval Kluger Lajos Pusztai
author_sort	Tao Qing
title	Germline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burden
title_short	Germline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burden
title_full	Germline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burden
title_fullStr	Germline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burden
title_full_unstemmed	Germline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burden
title_sort	germline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burden
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-05-01
description	Germline variants that affect the expression or function of protein-coding regions of cancer genes are associated with cancer susceptibility. Here, the authors show that a larger number of germline variants are present in early-onset cancers, while acquired somatic mutations are prevalent in cancers that develop at older age.
url	https://doi.org/10.1038/s41467-020-16293-7
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Germline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burden

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