Activation of α7-nAChRs Promotes the Clearance of α-Synuclein and Protects Against Apoptotic Cell Death Induced by Exogenous α-Synuclein Fibrils

Activation of α7-nAChRs Promotes the Clearance of α-Synuclein and Protects Against Apoptotic Cell Death Induced by Exogenous α-Synuclein Fibrils

Misfolding and abnormal aggregation of α-synuclein (αSyn) have been shown to increase the risk of developing Parkinson's disease (PD). Finding some way to reduce the aggregation of αSyn is particularly important for the treatment of PD. The main route in prion-like αSyn spreading is the choline...

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Bibliographic Details
Main Authors:	Jifeng Zhao, Yun Li, Yan Li, Shi Xu, Tingting Tao, Ye Hua, Ji Zhang, Yi Fan
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-02-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	α-synuclein apoptosis Parkinson's disease PNU-282987 nicotinic acetylcholine receptor
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2021.637319/full

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