Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts
Parkinson’s disease (PD) and Multiple System Atrophy (MSA) are characterized by the pathological accumulation of α-synuclein. Here the authors employ fluorescent probes, electron microscopy and NMR spectroscopy to study the properties of α-synuclein aggregates that were amplified from patient brain...
Main Authors: | Timo Strohäker, Byung Chul Jung, Shu-Hao Liou, Claudio O. Fernandez, Dietmar Riedel, Stefan Becker, Glenda M. Halliday, Marina Bennati, Woojin S. Kim, Seung-Jae Lee, Markus Zweckstetter |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2019-12-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-019-13564-w |
Similar Items
-
Structural characterization of alpha-synuclein aggregates seeded by patient material
by: Strohäker, Timo
Published: (2019) -
α-Synuclein Regulates Neuronal Cholesterol Efflux
by: Jen-Hsiang T. Hsiao, et al.
Published: (2017-10-01) -
Modeling α-Synuclein Propagation with Preformed Fibril Injections
by: Hyun Kyung Chung, et al.
Published: (2020-01-01) -
Modeling α-Synuclein Propagation with Preformed Fibril Injections
by: Hyun Kyung Chung, et al.
Published: (2019-09-01) -
Functionalization of α-synuclein fibrils
by: Simona Povilonienė, et al.
Published: (2015-01-01)