High molecular weight fibroblast growth factor-2 in the human heart is a potential target for prevention of cardiac remodeling.

High molecular weight fibroblast growth factor-2 in the human heart is a potential target for prevention of cardiac remodeling.

Fibroblast growth factor 2 (FGF-2) is a multifunctional protein synthesized as high (Hi-) and low (Lo-) molecular weight isoforms. Studies using rodent models showed that Hi- and Lo-FGF-2 exert distinct biological activities: after myocardial infarction, rat Lo-FGF-2, but not Hi-FGF-2, promoted sust...

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Bibliographic Details
Main Authors: Jon-Jon Santiago, Leslie J McNaughton, Navid Koleini, Xin Ma, Brian Bestvater, Barbara E Nickel, Robert R Fandrich, Jeffrey T Wigle, Darren H Freed, Rakesh C Arora, Elissavet Kardami
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4020823?pdf=render

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