Selective STAT3 Inhibitor Alantolactone Ameliorates Osteoarthritis via Regulating Chondrocyte Autophagy and Cartilage Homeostasis

Selective STAT3 Inhibitor Alantolactone Ameliorates Osteoarthritis via Regulating Chondrocyte Autophagy and Cartilage Homeostasis

Osteoarthritis (OA), which is identified by chronic pain, impacts the quality of life. Cartilage degradation and inflammation are the most relevant aspects involved in its development. Signal transducer and activator of transcription 3(STAT3), a member of the STATs protein family, is associated with...

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Bibliographic Details
Main Authors:	Wenbin Pei, Xiaojian Huang, Bowei Ni, Rui Zhang, Guangyi Niu, Hongbo You
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-09-01
Series:	Frontiers in Pharmacology
Subjects:	alantolactone osteoarthritis autophagy MMPs stat3 NF-κB
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2021.730312/full

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