Cortical oscillations that underlie visual selective attention are abnormal in adolescents with cerebral palsy
Abstract Adolescence is a critical period for the development and refinement of several higher-level cognitive functions, including visual selective attention. Clinically, it has been noted that adolescents with cerebral palsy (CP) may have deficits in selectively attending to objects within their v...
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2021-02-01
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doaj-64404671b4014929b350cd956f1310712021-03-11T12:21:05ZengNature Publishing GroupScientific Reports2045-23222021-02-011111810.1038/s41598-021-83898-3Cortical oscillations that underlie visual selective attention are abnormal in adolescents with cerebral palsyRashelle M. Hoffman0Christine M. Embury1Brandon J. Lew2Elizabeth Heinrichs-Graham3Tony W. Wilson4Max J. Kurz5Institute for Human Neuroscience, Boys Town National Research HospitalInstitute for Human Neuroscience, Boys Town National Research HospitalInstitute for Human Neuroscience, Boys Town National Research HospitalInstitute for Human Neuroscience, Boys Town National Research HospitalInstitute for Human Neuroscience, Boys Town National Research HospitalInstitute for Human Neuroscience, Boys Town National Research HospitalAbstract Adolescence is a critical period for the development and refinement of several higher-level cognitive functions, including visual selective attention. Clinically, it has been noted that adolescents with cerebral palsy (CP) may have deficits in selectively attending to objects within their visual field. This study aimed to evaluate the neural oscillatory activity in the ventral attention network while adolescents with CP performed a visual selective attention task. Adolescents with CP (N = 14; Age = 15.7 ± 4 years; MACS I–III; GMFCS I–IV) and neurotypical (NT) adolescents (N = 21; Age = 14.3 ± 2 years) performed the Eriksen flanker task while undergoing magnetoencephalographic (MEG) brain imaging. The participants reported the direction of a target arrow that was surrounded by congruent or incongruent flanking arrows. Compared with NT adolescents, adolescents with CP had slower responses and made more errors regarding the direction of the target arrow. The MEG results revealed that adolescents with CP had stronger alpha oscillations in the left insula when the flanking arrows were incongruent. Furthermore, participants that had more errors also tended to have stronger alpha oscillatory activity in this brain region. Altogether these results indicate that the aberrant activity seen in the left insula is associated with diminished visual selective attention function in adolescents with CP.https://doi.org/10.1038/s41598-021-83898-3 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rashelle M. Hoffman Christine M. Embury Brandon J. Lew Elizabeth Heinrichs-Graham Tony W. Wilson Max J. Kurz |
spellingShingle |
Rashelle M. Hoffman Christine M. Embury Brandon J. Lew Elizabeth Heinrichs-Graham Tony W. Wilson Max J. Kurz Cortical oscillations that underlie visual selective attention are abnormal in adolescents with cerebral palsy Scientific Reports |
author_facet |
Rashelle M. Hoffman Christine M. Embury Brandon J. Lew Elizabeth Heinrichs-Graham Tony W. Wilson Max J. Kurz |
author_sort |
Rashelle M. Hoffman |
title |
Cortical oscillations that underlie visual selective attention are abnormal in adolescents with cerebral palsy |
title_short |
Cortical oscillations that underlie visual selective attention are abnormal in adolescents with cerebral palsy |
title_full |
Cortical oscillations that underlie visual selective attention are abnormal in adolescents with cerebral palsy |
title_fullStr |
Cortical oscillations that underlie visual selective attention are abnormal in adolescents with cerebral palsy |
title_full_unstemmed |
Cortical oscillations that underlie visual selective attention are abnormal in adolescents with cerebral palsy |
title_sort |
cortical oscillations that underlie visual selective attention are abnormal in adolescents with cerebral palsy |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2021-02-01 |
description |
Abstract Adolescence is a critical period for the development and refinement of several higher-level cognitive functions, including visual selective attention. Clinically, it has been noted that adolescents with cerebral palsy (CP) may have deficits in selectively attending to objects within their visual field. This study aimed to evaluate the neural oscillatory activity in the ventral attention network while adolescents with CP performed a visual selective attention task. Adolescents with CP (N = 14; Age = 15.7 ± 4 years; MACS I–III; GMFCS I–IV) and neurotypical (NT) adolescents (N = 21; Age = 14.3 ± 2 years) performed the Eriksen flanker task while undergoing magnetoencephalographic (MEG) brain imaging. The participants reported the direction of a target arrow that was surrounded by congruent or incongruent flanking arrows. Compared with NT adolescents, adolescents with CP had slower responses and made more errors regarding the direction of the target arrow. The MEG results revealed that adolescents with CP had stronger alpha oscillations in the left insula when the flanking arrows were incongruent. Furthermore, participants that had more errors also tended to have stronger alpha oscillatory activity in this brain region. Altogether these results indicate that the aberrant activity seen in the left insula is associated with diminished visual selective attention function in adolescents with CP. |
url |
https://doi.org/10.1038/s41598-021-83898-3 |
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