Ameliorating effects of black seed oil on bisphenol A-induced abnormality of blood, hormone profile and gonadal histology of female mice

• Main Authors: Khaled Mahmud Sujan, Emdadul Hoque, Md. Iqramul Haque, Afrina Mustari, Mohammad Alam Miah, Md. Kamrul Islam
• Format: Article
• Language: English
• Published: Bangladesh Society for Microbiology, Immunology, and Advanced Biotechnology 2020-04-01
• Series: Journal of Advanced Biotechnology and Experimental Therapeutics
• Subjects: bisphenol-a; black seed oil; hematology; hormone; histopathology and mice
• Online Access: http://www.ejmanager.com/fulltextpdf.php?mno=72566

Bisphenol- A (BPA) is a multi-functional chemical produced in large volumes that is extensively used primarily in the manufacture of polycarbonate plastics and epoxy resins. Black seed oil (BSO) has been employed for many century as one of the main sources of nutrition and healthcare both for humans and animals. The study was carried out to investigate the effects of BPA and BSO on blood, hormone profile, and histopathological changes of ovary in female mice. Total 15 female Swiss Albino mice, aged between 6-8 weeks with an average body weight of 27.4±1g were randomly divided into 3 groups (5 mice/group). Group A act as vehicle control. Group B was administered 50 mg BPA /kg bw daily, while group C received both BPA and BSO and dose rate was 50 mg BPA /kg/day and 1ml BSO /kg/day respectively. Results revealed that Hb concentration, TEC and PCV (p [ J Adv Biotechnol Exp Ther 2020; 3(1.000): 43-48]