Murine heart gene expression during acute Chagasic myocarditis

• Main Authors: Andrés F. Henao-Martínez, Gabriel Parra-Henao
• Format: Article
• Language: English
• Published: Elsevier 2015-06-01
• Series: Genomics Data
• Subjects: Chagas; Acute; Myocarditis; Murine; Gene expression
• Online Access: http://www.sciencedirect.com/science/article/pii/S2213596015000264

Chagas disease is transmitted by the parasite, Trypanosoma cruzi. Acute infection is characterized by acute myocarditis, although it is largely asymptomatic. Initial cardiac insult could be a determinant to the posterior development of chronic Chagasic cardiomyopathy, usually after 10 years in only approximately 30% of chronically infected patients. Herein, we characterized the acute gene expression profiling in heart tissue of two strains of mice infected with T. cruzi (tulahuen strain) at 4 weeks and their respective controls. Gene sequence data are available at NCBI under GEO accession number: GSE63847. The output of the genes expression suggests differences in involvement of protein kinase B (AKT), NCAM1, HLA-DRA, and ubiquitin C genes networks. These gene activation differences may correlate with myocardial contractility during the acute infection.