Stress-mediated cis-element transcription factor interactions interconnecting primary and specialized metabolism in planta

Plant specialized metabolites are being used worldwide as therapeutic agents against several diseases. Since the precursors for specialized metabolites come through primary metabolism, extensive investigations have been carried out to understand the detailed connection between primary and specialize...

Full description

Bibliographic Details
Main Authors: S. A. Sheshadri, M. J. Nishanth, Bindu Simon
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Plant Science
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fpls.2016.01725/full
id doaj-642f4c217787412684954366c299a805
record_format Article
spelling doaj-642f4c217787412684954366c299a8052020-11-25T00:50:41ZengFrontiers Media S.A.Frontiers in Plant Science1664-462X2016-11-01710.3389/fpls.2016.01725213361Stress-mediated cis-element transcription factor interactions interconnecting primary and specialized metabolism in plantaS. A. Sheshadri0M. J. Nishanth1Bindu Simon2SASTRA UniversitySASTRA UniversitySASTRA UniversityPlant specialized metabolites are being used worldwide as therapeutic agents against several diseases. Since the precursors for specialized metabolites come through primary metabolism, extensive investigations have been carried out to understand the detailed connection between primary and specialized metabolism at various levels. Stress regulates the expression of primary and specialized metabolism genes at the transcriptional level via transcription factors binding to specific cis-elements. The presence of varied cis-element signatures upstream to different stress-responsive genes and their transcription factor binding patterns provide a prospective molecular link among diverse metabolic pathways. The pattern of occurrence of these cis-elements (overrepresentation/common) decipher the mechanism of stress-responsive upregulation of downstream genes, simultaneously forming a molecular bridge between primary and specialized metabolisms. Though many studies have been conducted on the transcriptional regulation of stress-mediated primary or specialized metabolism genes, but not much data is available with regard to cis-element signatures and transcription factors that simultaneously modulate both pathway genes. Hence, our major focus would be to present a comprehensive analysis of the stress-mediated interconnection between primary and specialized metabolism genes via the interaction between different transcription factors and their corresponding cis-elements. In future, this study could be further utilized for the overexpression of the specific transcription factors that upregulate both primary and specialized metabolism, thereby simultaneously improving the yield and therapeutic content of plants.http://journal.frontiersin.org/Journal/10.3389/fpls.2016.01725/fullGene Expression RegulationStress, Physiologicalprimary metabolismSpecialized Metabolismcis-elements
collection DOAJ
language English
format Article
sources DOAJ
author S. A. Sheshadri
M. J. Nishanth
Bindu Simon
spellingShingle S. A. Sheshadri
M. J. Nishanth
Bindu Simon
Stress-mediated cis-element transcription factor interactions interconnecting primary and specialized metabolism in planta
Frontiers in Plant Science
Gene Expression Regulation
Stress, Physiological
primary metabolism
Specialized Metabolism
cis-elements
author_facet S. A. Sheshadri
M. J. Nishanth
Bindu Simon
author_sort S. A. Sheshadri
title Stress-mediated cis-element transcription factor interactions interconnecting primary and specialized metabolism in planta
title_short Stress-mediated cis-element transcription factor interactions interconnecting primary and specialized metabolism in planta
title_full Stress-mediated cis-element transcription factor interactions interconnecting primary and specialized metabolism in planta
title_fullStr Stress-mediated cis-element transcription factor interactions interconnecting primary and specialized metabolism in planta
title_full_unstemmed Stress-mediated cis-element transcription factor interactions interconnecting primary and specialized metabolism in planta
title_sort stress-mediated cis-element transcription factor interactions interconnecting primary and specialized metabolism in planta
publisher Frontiers Media S.A.
series Frontiers in Plant Science
issn 1664-462X
publishDate 2016-11-01
description Plant specialized metabolites are being used worldwide as therapeutic agents against several diseases. Since the precursors for specialized metabolites come through primary metabolism, extensive investigations have been carried out to understand the detailed connection between primary and specialized metabolism at various levels. Stress regulates the expression of primary and specialized metabolism genes at the transcriptional level via transcription factors binding to specific cis-elements. The presence of varied cis-element signatures upstream to different stress-responsive genes and their transcription factor binding patterns provide a prospective molecular link among diverse metabolic pathways. The pattern of occurrence of these cis-elements (overrepresentation/common) decipher the mechanism of stress-responsive upregulation of downstream genes, simultaneously forming a molecular bridge between primary and specialized metabolisms. Though many studies have been conducted on the transcriptional regulation of stress-mediated primary or specialized metabolism genes, but not much data is available with regard to cis-element signatures and transcription factors that simultaneously modulate both pathway genes. Hence, our major focus would be to present a comprehensive analysis of the stress-mediated interconnection between primary and specialized metabolism genes via the interaction between different transcription factors and their corresponding cis-elements. In future, this study could be further utilized for the overexpression of the specific transcription factors that upregulate both primary and specialized metabolism, thereby simultaneously improving the yield and therapeutic content of plants.
topic Gene Expression Regulation
Stress, Physiological
primary metabolism
Specialized Metabolism
cis-elements
url http://journal.frontiersin.org/Journal/10.3389/fpls.2016.01725/full
work_keys_str_mv AT sasheshadri stressmediatedciselementtranscriptionfactorinteractionsinterconnectingprimaryandspecializedmetabolisminplanta
AT mjnishanth stressmediatedciselementtranscriptionfactorinteractionsinterconnectingprimaryandspecializedmetabolisminplanta
AT bindusimon stressmediatedciselementtranscriptionfactorinteractionsinterconnectingprimaryandspecializedmetabolisminplanta
_version_ 1725247122792513536