Lateral orbitofrontal cortex promotes trial-by-trial learning of risky, but not spatial, biases

Individual choices are not made in isolation but are embedded in a series of past experiences, decisions, and outcomes. The effects of past experiences on choices, often called sequential biases, are ubiquitous in perceptual and value-based decision-making, but their neural substrates are unclear. W...

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Main Authors:	Christine M Constantinople, Alex T Piet, Peter Bibawi, Athena Akrami, Charles Kopec, Carlos D Brody
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2019-11-01
Series:	eLife
Subjects:	decision-making orbitofrontal cortex sequential bias learning reinforcement learning
Online Access:	https://elifesciences.org/articles/49744

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spelling	doaj-642f31ed144d4547bf09819349976c932021-05-05T18:04:31ZengeLife Sciences Publications LtdeLife2050-084X2019-11-01810.7554/eLife.49744Lateral orbitofrontal cortex promotes trial-by-trial learning of risky, but not spatial, biasesChristine M Constantinople0https://orcid.org/0000-0003-4435-4460Alex T Piet1https://orcid.org/0000-0002-6529-1414Peter Bibawi2Athena Akrami3Charles Kopec4Carlos D Brody5https://orcid.org/0000-0002-4201-561XPrinceton Neuroscience Institute, Princeton University, Princeton, United StatesPrinceton Neuroscience Institute, Princeton University, Princeton, United StatesPrinceton Neuroscience Institute, Princeton University, Princeton, United StatesPrinceton Neuroscience Institute, Princeton University, Princeton, United States; Department of Molecular Biology, Princeton University, Princeton, United States; Howard Hughes Medical Institute, Princeton University, Princeton, United StatesPrinceton Neuroscience Institute, Princeton University, Princeton, United States; Department of Molecular Biology, Princeton University, Princeton, United StatesPrinceton Neuroscience Institute, Princeton University, Princeton, United States; Department of Molecular Biology, Princeton University, Princeton, United States; Howard Hughes Medical Institute, Princeton University, Princeton, United StatesIndividual choices are not made in isolation but are embedded in a series of past experiences, decisions, and outcomes. The effects of past experiences on choices, often called sequential biases, are ubiquitous in perceptual and value-based decision-making, but their neural substrates are unclear. We trained rats to choose between cued guaranteed and probabilistic rewards in a task in which outcomes on each trial were independent. Behavioral variability often reflected sequential effects, including increased willingness to take risks following risky wins, and spatial ‘win-stay/lose-shift’ biases. Recordings from lateral orbitofrontal cortex (lOFC) revealed encoding of reward history and receipt, and optogenetic inhibition of lOFC eliminated rats’ increased preference for risk following risky wins, but spared other sequential effects. Our data show that different sequential biases are neurally dissociable, and the lOFC’s role in adaptive behavior promotes learning of more abstract biases (here, biases for the risky option), but not spatial ones.https://elifesciences.org/articles/49744decision-makingorbitofrontal cortexsequential biaslearningreinforcement learning
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Christine M Constantinople Alex T Piet Peter Bibawi Athena Akrami Charles Kopec Carlos D Brody
spellingShingle	Christine M Constantinople Alex T Piet Peter Bibawi Athena Akrami Charles Kopec Carlos D Brody Lateral orbitofrontal cortex promotes trial-by-trial learning of risky, but not spatial, biases eLife decision-making orbitofrontal cortex sequential bias learning reinforcement learning
author_facet	Christine M Constantinople Alex T Piet Peter Bibawi Athena Akrami Charles Kopec Carlos D Brody
author_sort	Christine M Constantinople
title	Lateral orbitofrontal cortex promotes trial-by-trial learning of risky, but not spatial, biases
title_short	Lateral orbitofrontal cortex promotes trial-by-trial learning of risky, but not spatial, biases
title_full	Lateral orbitofrontal cortex promotes trial-by-trial learning of risky, but not spatial, biases
title_fullStr	Lateral orbitofrontal cortex promotes trial-by-trial learning of risky, but not spatial, biases
title_full_unstemmed	Lateral orbitofrontal cortex promotes trial-by-trial learning of risky, but not spatial, biases
title_sort	lateral orbitofrontal cortex promotes trial-by-trial learning of risky, but not spatial, biases
publisher	eLife Sciences Publications Ltd
series	eLife
issn	2050-084X
publishDate	2019-11-01
description	Individual choices are not made in isolation but are embedded in a series of past experiences, decisions, and outcomes. The effects of past experiences on choices, often called sequential biases, are ubiquitous in perceptual and value-based decision-making, but their neural substrates are unclear. We trained rats to choose between cued guaranteed and probabilistic rewards in a task in which outcomes on each trial were independent. Behavioral variability often reflected sequential effects, including increased willingness to take risks following risky wins, and spatial ‘win-stay/lose-shift’ biases. Recordings from lateral orbitofrontal cortex (lOFC) revealed encoding of reward history and receipt, and optogenetic inhibition of lOFC eliminated rats’ increased preference for risk following risky wins, but spared other sequential effects. Our data show that different sequential biases are neurally dissociable, and the lOFC’s role in adaptive behavior promotes learning of more abstract biases (here, biases for the risky option), but not spatial ones.
topic	decision-making orbitofrontal cortex sequential bias learning reinforcement learning
url	https://elifesciences.org/articles/49744
work_keys_str_mv	AT christinemconstantinople lateralorbitofrontalcortexpromotestrialbytriallearningofriskybutnotspatialbiases AT alextpiet lateralorbitofrontalcortexpromotestrialbytriallearningofriskybutnotspatialbiases AT peterbibawi lateralorbitofrontalcortexpromotestrialbytriallearningofriskybutnotspatialbiases AT athenaakrami lateralorbitofrontalcortexpromotestrialbytriallearningofriskybutnotspatialbiases AT charleskopec lateralorbitofrontalcortexpromotestrialbytriallearningofriskybutnotspatialbiases AT carlosdbrody lateralorbitofrontalcortexpromotestrialbytriallearningofriskybutnotspatialbiases
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Lateral orbitofrontal cortex promotes trial-by-trial learning of risky, but not spatial, biases

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