Novel Synthesis Method of Micronized Ti-Zeolite Na-A and Cytotoxic Activity of Its Silver Exchanged Form

Novel Synthesis Method of Micronized Ti-Zeolite Na-A and Cytotoxic Activity of Its Silver Exchanged Form

The core-shell method is used as a novel synthetic process of micronized Ti-Zeolite Na-A which involves calcination at 700°C of coated Egyptian Kaolin with titanium tetrachloride in acidic medium as the first step. The produced Ti-coated metakaolinite is subjected to microwave irradiation at low tem...

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Main Authors: H. F. Youssef, W. H. Hegazy, H. H. Abo-almaged, G. T. El-Bassyouni
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:Bioinorganic Chemistry and Applications
Online Access:http://dx.doi.org/10.1155/2015/428121
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spelling doaj-6420875d94f74f3d95f2be343f73ab642020-11-24T22:00:02ZengHindawi LimitedBioinorganic Chemistry and Applications1565-36331687-479X2015-01-01201510.1155/2015/428121428121Novel Synthesis Method of Micronized Ti-Zeolite Na-A and Cytotoxic Activity of Its Silver Exchanged FormH. F. Youssef0W. H. Hegazy1H. H. Abo-almaged2G. T. El-Bassyouni3Refractories, Ceramics and Building Materials Department, National Research Centre (NRC), Dokki, Cairo 12622, EgyptDepartment of Chemistry, Faculty of Science, Suez University, Suez 43533, EgyptRefractories, Ceramics and Building Materials Department, National Research Centre (NRC), Dokki, Cairo 12622, EgyptBiomaterials Department, National Research Centre (NRC), Dokki, Cairo 12622, EgyptThe core-shell method is used as a novel synthetic process of micronized Ti-Zeolite Na-A which involves calcination at 700°C of coated Egyptian Kaolin with titanium tetrachloride in acidic medium as the first step. The produced Ti-coated metakaolinite is subjected to microwave irradiation at low temperature of 80°C for 2 h. The prepared micronized Ti-containing Zeolites-A (Ti-Z-A) is characterized by FTIR, XRF, XRD, SEM, and EDS elemental analysis. Ag-exchanged form of Ti-Z-Ag is also prepared and characterized. The Wt% of silver exchanged onto the Ti-Zeolite structure was determined by atomic absorption spectra. The in vitro cytotoxic activity of Ti-Z-Ag against human hepatocellular carcinoma cell line (HePG2), colon cell line carcinoma (HCT116), lung carcinoma cell line (A549), and human Caucasian breast adenocarcinoma (MCF7) is reported. The results were promising and revealed that the exchanged Ag form of micronized Ti-Zeolite-A can be used as novel antitumor drug.http://dx.doi.org/10.1155/2015/428121
collection DOAJ
language English
format Article
sources DOAJ
author H. F. Youssef
W. H. Hegazy
H. H. Abo-almaged
G. T. El-Bassyouni
spellingShingle H. F. Youssef
W. H. Hegazy
H. H. Abo-almaged
G. T. El-Bassyouni
Novel Synthesis Method of Micronized Ti-Zeolite Na-A and Cytotoxic Activity of Its Silver Exchanged Form
Bioinorganic Chemistry and Applications
author_facet H. F. Youssef
W. H. Hegazy
H. H. Abo-almaged
G. T. El-Bassyouni
author_sort H. F. Youssef
title Novel Synthesis Method of Micronized Ti-Zeolite Na-A and Cytotoxic Activity of Its Silver Exchanged Form
title_short Novel Synthesis Method of Micronized Ti-Zeolite Na-A and Cytotoxic Activity of Its Silver Exchanged Form
title_full Novel Synthesis Method of Micronized Ti-Zeolite Na-A and Cytotoxic Activity of Its Silver Exchanged Form
title_fullStr Novel Synthesis Method of Micronized Ti-Zeolite Na-A and Cytotoxic Activity of Its Silver Exchanged Form
title_full_unstemmed Novel Synthesis Method of Micronized Ti-Zeolite Na-A and Cytotoxic Activity of Its Silver Exchanged Form
title_sort novel synthesis method of micronized ti-zeolite na-a and cytotoxic activity of its silver exchanged form
publisher Hindawi Limited
series Bioinorganic Chemistry and Applications
issn 1565-3633
1687-479X
publishDate 2015-01-01
description The core-shell method is used as a novel synthetic process of micronized Ti-Zeolite Na-A which involves calcination at 700°C of coated Egyptian Kaolin with titanium tetrachloride in acidic medium as the first step. The produced Ti-coated metakaolinite is subjected to microwave irradiation at low temperature of 80°C for 2 h. The prepared micronized Ti-containing Zeolites-A (Ti-Z-A) is characterized by FTIR, XRF, XRD, SEM, and EDS elemental analysis. Ag-exchanged form of Ti-Z-Ag is also prepared and characterized. The Wt% of silver exchanged onto the Ti-Zeolite structure was determined by atomic absorption spectra. The in vitro cytotoxic activity of Ti-Z-Ag against human hepatocellular carcinoma cell line (HePG2), colon cell line carcinoma (HCT116), lung carcinoma cell line (A549), and human Caucasian breast adenocarcinoma (MCF7) is reported. The results were promising and revealed that the exchanged Ag form of micronized Ti-Zeolite-A can be used as novel antitumor drug.
url http://dx.doi.org/10.1155/2015/428121
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