Inherently Chiral Calixarenes: Synthesis, Optical Resolution, Chiral Recognition and Asymmetric Catalysis

• Main Authors: Shao-Yong Li, Yao-Wei Xu, Cheng-Yong Su, Jun-Min Liu
• Format: Article
• Language: English
• Published: MDPI AG 2011-01-01
• Series: International Journal of Molecular Sciences
• Subjects: inherently chiral calixarene; synthesis; optical resolution; chiral recognition; asymmetric catalysis
• Online Access: http://www.mdpi.com/1422-0067/12/1/429/

Inherently chiral calixarenes, whose chirality is based on the absence of a planar symmetry or an inversion center in the molecules as a whole through the asymmetric array of several achiral groups upon the three-dimensional calix-skeletons, are challenging and attractive chiral molecules, because of their potential in supramolecular chemistry. The synthesis and optical resolution of all varieties of inherently chiral calixarenes are systematically discussed and classified, and their applications in chiral recognition and asymmetric catalysis are thoroughly illustrated in this review.