MLL-ENL Inhibits Polycomb Repressive Complex 1 to Achieve Efficient Transformation of Hematopoietic Cells

MLL-ENL Inhibits Polycomb Repressive Complex 1 to Achieve Efficient Transformation of Hematopoietic Cells

Stimulation of transcriptional elongation is a key activity of leukemogenic MLL fusion proteins. Here, we provide evidence that MLL-ENL also inhibits Polycomb-mediated silencing as a prerequisite for efficient transformation. Biochemical studies identified ENL as a scaffold that contacted the elong...

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Bibliographic Details
Main Authors:	Emanuel Maethner, Maria-Paz Garcia-Cuellar, Constanze Breitinger, Sylvia Takacova, Vladimir Divoky, Jay L. Hess, Robert K. Slany
Format:	Article
Language:	English
Published:	Elsevier 2013-05-01
Series:	Cell Reports
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124713001629

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