Rare Presentation of Metastatic Cystic Trophoblastic Tumor in a Patient Without Prior Chemotherapy

Rare Presentation of Metastatic Cystic Trophoblastic Tumor in a Patient Without Prior Chemotherapy

Cystic trophoblastic tumor (CTT) is a rare testicular germ cell tumor (GCT) predominantly seen in post-chemotherapy patients. It is prognostically similar to teratoma and requires no additional chemotherapy in the absence of a nonteratomatous GCT component. We report a case of metastatic CTT in a pa...

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Bibliographic Details
Main Authors: Michael L. Wang, Jonathan B. McHugh, Alon Z. Weizer, Todd M. Morgan, Arul M. Chinnaiyan, Andrew P. Sciallis, Amir Lagstein, Daniel E. Spratt, Rohit Mehra
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Urology Case Reports
Subjects:
Testicular germ cell tumor
Cystic trophoblastic tumor
Choriocarcinoma
SALL4
Online Access:http://www.sciencedirect.com/science/article/pii/S2214442017300852
Description
Summary:Cystic trophoblastic tumor (CTT) is a rare testicular germ cell tumor (GCT) predominantly seen in post-chemotherapy patients. It is prognostically similar to teratoma and requires no additional chemotherapy in the absence of a nonteratomatous GCT component. We report a case of metastatic CTT in a patient with primary testicular teratoma without prior chemotherapy. Retroperitoneal lymph node metastases contained teratoma, embryonal carcinoma, and CTT. The CTT was β-hCG positive and SALL4 negative by immunohistochemistry (IHC). CTT can arise in metastatic testicular GCT in treatment naïve patients. An important differential diagnosis is choriocarcinoma due to treatment implications, and SALL4 IHC may help.
ISSN:2214-4420

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