Novel Oncolytic Virus Armed with Cancer Suicide Gene and Normal Vasculogenic Gene for Improved Anti-Tumor Activity

Novel Oncolytic Virus Armed with Cancer Suicide Gene and Normal Vasculogenic Gene for Improved Anti-Tumor Activity

Here, we developed a novel oncolytic vaccinia virus (NOV) with the dual advantages of cancer selectivity and normal vessel reconstructive activity by replacing the viral thymidine kinase (vTk) and vaccinia growth factor (VGF) genes with genes encoding TNF-related apoptosis-inducing ligand (TRAIL) an...

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Bibliographic Details
Main Authors: Su-Nam Jeong, So Young Yoo
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cancers
Subjects:
oncolytic virus
angiopoietin 1
TRAIL
Online Access:https://www.mdpi.com/2072-6694/12/5/1070

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