STK295900, a dual inhibitor of topoisomerase 1 and 2, induces G(2) arrest in the absence of DNA damage.

STK295900, a dual inhibitor of topoisomerase 1 and 2, induces G(2) arrest in the absence of DNA damage.

STK295900, a small synthetic molecule belonging to a class of symmetric bibenzimidazoles, exhibits antiproliferative activity against various human cancer cell lines from different origins. Examining the effect of STK295900 in HeLa cells indicates that it induces G(2) phase arrest without invoking D...

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Main Authors: Sun-Ok Kim, Krisada Sakchaisri, N R Thimmegowda, Nak Kyun Soung, Jae-Hyuk Jang, Young Sang Kim, Kyung Sang Lee, Yong Tae Kwon, Yukihiro Asami, Jong Seog Ahn, Raymond Leo Erikson, Bo Yeon Kim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3551932?pdf=render

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