Nutrilyzer: A Tool for Deciphering Atomic Stoichiometry of Differentially Expressed Paralogous Proteins

Nutrilyzer: A Tool for Deciphering Atomic Stoichiometry of Differentially Expressed Paralogous Proteins

Organisms try to maintain homeostasis by balanced uptake of nutrients from their environment. From an atomic perspective this means that, for example, carbon:nitrogen:sulfur ratios are kept within given limits. Upon limitation of, for example, sulfur, its acquisition is triggered. For yeast it was s...

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Main Authors: Lotz Katrin, Schreiber Falk, Wünschiers Röbbe
Format: Article
Language:English
Published: De Gruyter 2012-06-01
Series:Journal of Integrative Bioinformatics
Online Access:https://doi.org/10.1515/jib-2012-196
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spelling doaj-63f4c74cce6a4d2e9232d7ebb215bb372021-09-06T19:40:31ZengDe GruyterJournal of Integrative Bioinformatics1613-45162012-06-0192465210.1515/jib-2012-196biecoll-jib-2012-196Nutrilyzer: A Tool for Deciphering Atomic Stoichiometry of Differentially Expressed Paralogous ProteinsLotz Katrin0Schreiber Falk1Wünschiers Röbbe2SunGene GmbH, Corrensstr. 3, D-06466 Gatersleben, GermanyLeibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben, Corrensstr. 3, D-06466 Gatersleben, Germany GermanyUniversity of Applied Sciences Mittweida, Technikumplatz 17, 09648 Mittweida, GermanyOrganisms try to maintain homeostasis by balanced uptake of nutrients from their environment. From an atomic perspective this means that, for example, carbon:nitrogen:sulfur ratios are kept within given limits. Upon limitation of, for example, sulfur, its acquisition is triggered. For yeast it was shown that transporters and enzymes involved in sulfur up- take are encoded as paralogous genes that express different isoforms. Sulfur deprivation leads to up-regulation of isoforms that are poor in sulfur-containing amino acids, that is, methinone and cysteine. Accordingly, sulfur-rich isoforms are down-regulated.https://doi.org/10.1515/jib-2012-196
collection DOAJ
language English
format Article
sources DOAJ
author Lotz Katrin
Schreiber Falk
Wünschiers Röbbe
spellingShingle Lotz Katrin
Schreiber Falk
Wünschiers Röbbe
Nutrilyzer: A Tool for Deciphering Atomic Stoichiometry of Differentially Expressed Paralogous Proteins
Journal of Integrative Bioinformatics
author_facet Lotz Katrin
Schreiber Falk
Wünschiers Röbbe
author_sort Lotz Katrin
title Nutrilyzer: A Tool for Deciphering Atomic Stoichiometry of Differentially Expressed Paralogous Proteins
title_short Nutrilyzer: A Tool for Deciphering Atomic Stoichiometry of Differentially Expressed Paralogous Proteins
title_full Nutrilyzer: A Tool for Deciphering Atomic Stoichiometry of Differentially Expressed Paralogous Proteins
title_fullStr Nutrilyzer: A Tool for Deciphering Atomic Stoichiometry of Differentially Expressed Paralogous Proteins
title_full_unstemmed Nutrilyzer: A Tool for Deciphering Atomic Stoichiometry of Differentially Expressed Paralogous Proteins
title_sort nutrilyzer: a tool for deciphering atomic stoichiometry of differentially expressed paralogous proteins
publisher De Gruyter
series Journal of Integrative Bioinformatics
issn 1613-4516
publishDate 2012-06-01
description Organisms try to maintain homeostasis by balanced uptake of nutrients from their environment. From an atomic perspective this means that, for example, carbon:nitrogen:sulfur ratios are kept within given limits. Upon limitation of, for example, sulfur, its acquisition is triggered. For yeast it was shown that transporters and enzymes involved in sulfur up- take are encoded as paralogous genes that express different isoforms. Sulfur deprivation leads to up-regulation of isoforms that are poor in sulfur-containing amino acids, that is, methinone and cysteine. Accordingly, sulfur-rich isoforms are down-regulated.
url https://doi.org/10.1515/jib-2012-196
work_keys_str_mv AT lotzkatrin nutrilyzeratoolfordecipheringatomicstoichiometryofdifferentiallyexpressedparalogousproteins
AT schreiberfalk nutrilyzeratoolfordecipheringatomicstoichiometryofdifferentiallyexpressedparalogousproteins
AT wunschiersrobbe nutrilyzeratoolfordecipheringatomicstoichiometryofdifferentiallyexpressedparalogousproteins
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