Nitric oxide/cGMP pathway signaling actively down-regulates α<sub>4</sub>β<sub>1</sub>-integrin affinity: an unexpected mechanism for inducing cell de-adhesion

Nitric oxide/cGMP pathway signaling actively down-regulates α<sub>4</sub>β<sub>1</sub>-integrin affinity: an unexpected mechanism for inducing cell de-adhesion

<p>Abstract</p> <p>Background</p> <p>Integrin activation in response to inside-out signaling serves as the basis for rapid leukocyte arrest on endothelium, migration, and mobilization of immune cells. Integrin-dependent adhesion is controlled by the conformational state...

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Bibliographic Details
Main Authors:	Sklar Larry A, Smagley Yelena, Chigaev Alexandre
Format:	Article
Language:	English
Published:	BMC 2011-05-01
Series:	BMC Immunology
Online Access:	http://www.biomedcentral.com/1471-2172/12/28

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