Prevention of renal apoB retention is protective against diabetic nephropathy: role of TGF-β inhibition[S]

Prevention of renal apoB retention is protective against diabetic nephropathy: role of TGF-β inhibition[S]

Animal studies demonstrate that hyperlipidemia and renal lipid accumulation contribute to the pathogenesis of diabetic nephropathy (DN). We previously demonstrated that renal lipoproteins colocalize with biglycan, a renal proteoglycan. The purpose of this study was to determine whether prevention of...

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Bibliographic Details
Main Authors: Patricia G. Wilson, Joel C. Thompson, Meghan H. Yoder, Richard Charnigo, Lisa R. Tannock
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Journal of Lipid Research
Subjects:
cholesterol
diabetes
extracellular matrix
kidney
proteoglycans
biglycan
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520335537

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