Genetic Approach to Elucidate the Role of Cyclophilin D in Traumatic Brain Injury Pathology

Genetic Approach to Elucidate the Role of Cyclophilin D in Traumatic Brain Injury Pathology

Cyclophilin D (CypD) has been shown to play a critical role in mitochondrial permeability transition pore (mPTP) opening and the subsequent cell death cascade. Studies consistently demonstrate that mitochondrial dysfunction, including mitochondrial calcium overload and mPTP opening, is essential to...

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Bibliographic Details
Main Authors: Ryan D. Readnower, William Brad Hubbard, Olivia J. Kalimon, James W. Geddes, Patrick G. Sullivan
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cells
Subjects:
controlled cortical impact
mitochondrial bioenergetics
mitochondria
cyclosporin a
NIM811
mitochondrial permeability transition
Online Access:https://www.mdpi.com/2073-4409/10/2/199

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https://www.mdpi.com/2073-4409/10/2/199

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