N-acetylcysteine and allopurinol confer synergy in attenuating myocardial ischemia injury via restoring HIF-1α/HO-1 signaling in diabetic rats.

N-acetylcysteine and allopurinol confer synergy in attenuating myocardial ischemia injury via restoring HIF-1α/HO-1 signaling in diabetic rats.

To determine whether or not the antioxidants N-acetylcysteine (NAC) and allopurinol (ALP) confer synergistic cardioprotection against myocardial ischemia/reperfusion (MI/R) injury by stabilizing hypoxia inducible factor 1α (HIF-1α)/heme oxygenase 1 (HO-1) signaling in diabetic myocardium.Control or...

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Bibliographic Details
Main Authors: Xiaowen Mao, Tingting Wang, Yanan Liu, Michael G Irwin, Jing-song Ou, Xiao-long Liao, Xia Gao, Yuan Xu, Kwok F J Ng, Paul M Vanhoutte, Zhengyuan Xia
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3715528?pdf=render

Internet

http://europepmc.org/articles/PMC3715528?pdf=render

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