Intravitreal Injection of Ranibizumab and CTGF shRNA Improves Retinal Gene Expression and Microvessel Ultrastructure in a Rodent Model of Diabetes

Intravitreal Injection of Ranibizumab and CTGF shRNA Improves Retinal Gene Expression and Microvessel Ultrastructure in a Rodent Model of Diabetes

Therapeutic modalities targeting vascular endothelial growth factor (VEGF) have been used to treat neovascularization and macular edema. However, anti-VEGF treatment alone may cause up-regulation of connective tissue growth factor (CTGF) in the retina, increasing the risk of fibrosis and tractional...

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Bibliographic Details
Main Authors: Bojie Hu, Yan Zhang, Qing Zeng, Qian Han, Lijuan Zhang, Mian Liu, Xiaorong Li
Format: Article
Language:English
Published: MDPI AG 2014-01-01
Series:International Journal of Molecular Sciences
Subjects:
vascular endothelial growth factor
connective tissue growth factor
diabetic retinopathy
ranibizumab
shRNA
Online Access:http://www.mdpi.com/1422-0067/15/1/1606

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