Synthetic studies towards bottromycin

Synthetic studies towards bottromycin

Thio-Ugi reactions are described as an excellent synthetic tool for the synthesis of sterically highly hindered endothiopeptides. S-Methylation and subsequent amidine formation can be carried out in an inter- as well as in an intramolecular fashion. The intramolecular approach allows the synthesis o...

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Bibliographic Details
Main Authors: Stefanie Ackermann, Hans-Georg Lerchen, Dieter Häbich, Angelika Ullrich, Uli Kazmaier
Format: Article
Language:English
Published: Beilstein-Institut 2012-10-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
amidines
antibiotics
bottromycin
peptides
thiopeptides
Ugi reactions
Online Access:https://doi.org/10.3762/bjoc.8.189
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spelling doaj-63dc55d6a55445839d0ecd21f7cf5cd42021-02-02T07:50:17ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972012-10-01811652165610.3762/bjoc.8.1891860-5397-8-189Synthetic studies towards bottromycinStefanie Ackermann0Hans-Georg Lerchen1Dieter Häbich2Angelika Ullrich3Uli Kazmaier4Institute of Organic Chemistry, Saarland University, P.O. Box 151150, 66041 Saarbrücken, GermanyBayer Pharma Aktiengesellschaft, Aprather Weg 18a, 42113 Wuppertal, GermanyBayer Pharma Aktiengesellschaft, Aprather Weg 18a, 42113 Wuppertal, GermanyInstitute of Organic Chemistry, Saarland University, P.O. Box 151150, 66041 Saarbrücken, GermanyInstitute of Organic Chemistry, Saarland University, P.O. Box 151150, 66041 Saarbrücken, GermanyThio-Ugi reactions are described as an excellent synthetic tool for the synthesis of sterically highly hindered endothiopeptides. S-Methylation and subsequent amidine formation can be carried out in an inter- as well as in an intramolecular fashion. The intramolecular approach allows the synthesis of the bottromycin ring system in a straightforward manner.https://doi.org/10.3762/bjoc.8.189amidinesantibioticsbottromycinpeptidesthiopeptidesUgi reactions
collection DOAJ
language English
format Article
sources DOAJ
author Stefanie Ackermann
Hans-Georg Lerchen
Dieter Häbich
Angelika Ullrich
Uli Kazmaier
spellingShingle Stefanie Ackermann
Hans-Georg Lerchen
Dieter Häbich
Angelika Ullrich
Uli Kazmaier
Synthetic studies towards bottromycin
Beilstein Journal of Organic Chemistry
amidines
antibiotics
bottromycin
peptides
thiopeptides
Ugi reactions
author_facet Stefanie Ackermann
Hans-Georg Lerchen
Dieter Häbich
Angelika Ullrich
Uli Kazmaier
author_sort Stefanie Ackermann
title Synthetic studies towards bottromycin
title_short Synthetic studies towards bottromycin
title_full Synthetic studies towards bottromycin
title_fullStr Synthetic studies towards bottromycin
title_full_unstemmed Synthetic studies towards bottromycin
title_sort synthetic studies towards bottromycin
publisher Beilstein-Institut
series Beilstein Journal of Organic Chemistry
issn 1860-5397
publishDate 2012-10-01
description Thio-Ugi reactions are described as an excellent synthetic tool for the synthesis of sterically highly hindered endothiopeptides. S-Methylation and subsequent amidine formation can be carried out in an inter- as well as in an intramolecular fashion. The intramolecular approach allows the synthesis of the bottromycin ring system in a straightforward manner.
topic amidines
antibiotics
bottromycin
peptides
thiopeptides
Ugi reactions
url https://doi.org/10.3762/bjoc.8.189
work_keys_str_mv AT stefanieackermann syntheticstudiestowardsbottromycin
AT hansgeorglerchen syntheticstudiestowardsbottromycin
AT dieterhabich syntheticstudiestowardsbottromycin
AT angelikaullrich syntheticstudiestowardsbottromycin
AT ulikazmaier syntheticstudiestowardsbottromycin
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