| Summary: | Physical activity can raise the level of circulating HDL cholesterol. Preβ1-HDL is thought to be either the initial acceptor of cellular cholesterol or virtually the first particle in the pathway of the formation of HDL from apolipoprotein A-I and cellular lipids. We have therefore sought to identify preβ1-HDL in arterial and venous circulations of exercising legs in healthy individuals and in subjects with stable Type 2 diabetes mellitus. Blood samples were taken simultaneously from the femoral artery and vein before and after 25 min cycling exercise. The major findings were, first, that exercise significantly increased plasma concentration of preβ1-HDL (20% increase, P < 0.05) and second, that the preβ1-HDL concentration was significantly higher in the venous compared with the arterial blood both before and after exercise in both diabetics and controls.In the combined population, formation of preβ1-HDL at rest was 9.9 ± 5.2 mg/min and exercise enhanced preβ1-HDL formation 6.6-fold in both groups.
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