The effect of essential oil of Achillea wilhelmsii flowers on cisplatin-induced hepatotoxicity

• Main Authors: Sahar Ghanbari, Leila Amjad, Kahin Shahanipur
• Format: Article
• Language: fas
• Published: Kashan University of Medical Sciences and Health Services 2017-11-01
• Series: Fiyz̤
• Subjects: Achillea wilhelmsii; Essential oil; Cisplatin
• Online Access: http://feyz.kaums.ac.ir/article-1-3212-en.html

Background: The essential oil of Achillea wilhelmsii has‎ anti-inflammatory and antioxidant properties. Cisplatin is one of the most important anticancer drugs that are widely used to treat various types of cancers. This study aimed at examining the effects of the essential oil of A. wilhelmsii flowers on cisplatin-induced hepatotoxicity in rats. Materials and Methods: In this study, 36 male Wistar rats weighing 200-250 g were divided into 6 groups: 1) control, 2) cisplatin (0.4 mg/kg), 3) cisplatin and essential oil (30 mg/kg), 4) cisplatin and essential oil (60 mg/kg), 5) essential oil (30 mg/kg) and 6) essential oil (60 mg/kg).The injection was performed in the groups every day for 8 weeks. Then, serum levels of liver enzymes were measured and the liver tissue was removed for histopathological studies. Results: The results showed no significant changes in the albumin level (P>0.05). However, the activities of hepatic factors ALT, AST, ALP and bilirubin were decreased significantly in the groups received essential oil 30 and 60 mg/kg + cisplatin and in groups only received the essential oil 30 and 60 mg/kg compared to the cisplatin group (P<0.05). Histopathological analysis of liver showed a significant difference in all groups compared to the control group, which this difference in the group received essential oil 60 mg/kg + cisplatin was higher than other groups. Conclusion: The essential oil of A. wilhelmsii decreases serum levels of liver factors and bilirubin against cisplatin.