Synthesis of Functionalized Indoles via Palladium-Catalyzed Cyclization of <i>N</i>-(2-allylphenyl) Benzamide: A Method for Synthesis of Indomethacin Precursor

Synthesis of Functionalized Indoles via Palladium-Catalyzed Cyclization of <i>N</i>-(2-allylphenyl) Benzamide: A Method for Synthesis of Indomethacin Precursor

We developed an efficient method for synthesis of substituted <i>N</i>-benzoylindole via Pd(II)-catalyzed C&#8722;H functionalization of substituted <i>N</i>-(2-allylphenyl)benzamide. The reaction showed a broad substrate scope (including <i>N</i>-acetyl and &...

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Bibliographic Details
Main Authors: Zhe Chang, Tong Ma, Yu Zhang, Zheng Dong, Heng Zhao, Depeng Zhao
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Molecules
Subjects:
palladium
indole
indomethacin
c-h functionalization
Online Access:https://www.mdpi.com/1420-3049/25/5/1233

Internet

https://www.mdpi.com/1420-3049/25/5/1233

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