Effect of circuit exercise training combined with drug therapy on glucose lipid metabolism and microinflammatory state in T2DM patients

• Main Authors: Xiao-Li Tang, Hai-Mei Ye, Xiao-Qin Wang, Lei Dai, Run-Ping Liu
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-10-01
• Series: Journal of Hainan Medical University
• Subjects: type 2 diabetes mellitus; circuit exercise training; insulin resistance; adipocytokine; inflammatory response
• Online Access: http://www.hnykdxxb.com/PDF/201720/08.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To study the effect of circuit exercise training combined with drug therapy on glucose lipid metabolism and microinflammatory state in T2DM patients. Methods: Patients with newly diagnosed T2DM who were treated in Dazhou Integrated Traditional Chinese and Western Medicine Hospital between June 2014 and October 2016 were selected and randomly divided into training intervention group and routine intervention group who received circuit exercise training intervention and routine exercise intervention respectively. The contents of glucose lipid metabolism indexes and inflammatory cytokines in serum as well as the contents of inflammatory cells in peripheral blood were determined before intervention and 8 weeks after intervention. Results: Serum FBG, F-Ins, HbA1c%, FFA, TC, LDL-C, ox-LDL, Chemerin, Resistin, IL-6, MCP-1 and CRP contents as well as peripheral blood CD14+CD16+ cell contents of both groups of patients after intervention were lower than those before intervention while HDL-C, ADP and Vaspin contents were higher than those before intervention, and serum FBG, F-Ins, HbA1c%, FFA, TC, LDL-C, ox-LDL, Chemerin, Resistin, IL-6, MCP-1 and CRP contents as well as peripheral blood CD14+CD16+ cell content of training intervention group after intervention were lower than those of routine intervention group while HDL-C, ADP and Vaspin contents were higher than those of routine intervention group. Conclusion: Circuit exercise training for T2DM can be more effective in improving glucose lipid metabolism and inhibiting inflammatory response.