Lipid composition and Na+,K+-ATPase activity in erythrocyte membranes of patients with type 2 diabetes mellitusand dyslipoproteinemia

• Main Authors: Elena Borisovna Kravets, Elena Alekseevna Stepovaya, Tatiana Yur'evna Koshchevets, Olesya Dmitrievna Medvedeva, Natalya Mikhailovna Yakovleva, Oyuunchimeg Yadmaa, Elena Alexandrovna Ananina
• Format: Article
• Language: English
• Published: Endocrinology Research Centre 2010-03-01
• Series: Сахарный диабет
• Subjects: type 2 diabetes mellitus; diabetic dyslipoproteinemia; erythrocyte; membrane; lipids; na+; k+-atpase activity
• Online Access: https://dia-endojournals.ru/dia/article/viewFile/6015/3774
• ISSN: 2072-0351; 2072-0378

Aim. To study lipid composition and Na+,K+-Na+,K+-ATPase activity in erythrocyte membranes of patients with type 2 diabetes mellitus and dyslipoproteinemia. Materials and methods. The study included 40 patients (22 men and 18 women) aged 40-65 years with DM2. Results. The patients had abnormal lipid composition and impaired Na+,K+-Na+,K+-ATPase activity in erythrocyte membranes. The magnitude of thesechanges depended on the duration of pathology, severity of diabetic dyslipoproteinemia, and quality of compensation of carbohydrate metabolism. Conclusion. Aim. Investigation of lipid dysorganization in erythrocyte membranes in patients with type 2 diabetes mellitus yields data for the developmentof therapeutic modalities to correct dyslipoproteinemia.