MSCs‑derived exosomes attenuate ischemia-reperfusion brain injury and inhibit microglia apoptosis might via exosomal miR-26a-5p mediated suppression of CDK6

MSCs‑derived exosomes attenuate ischemia-reperfusion brain injury and inhibit microglia apoptosis might via exosomal miR-26a-5p mediated suppression of CDK6

Abstract Background This study aimed to explore the role of mesenchymal stromal cells (MSCs)-derived exosomes (MSCs-Exo) in the cerebral ischemia–reperfusion (I/R) injury. Methods Exosomes were isolated from MSCs of adult C57BL/6J mice by the gradient centrifugation method. The expression of miR-26a...

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Bibliographic Details
Main Authors: Chang Cheng, Xiuying Chen, Yuhan Wang, Wenchao Cheng, Xuzheng Zuo, Weiju Tang, Wen Huang
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Molecular Medicine
Subjects:
Exosomes
Mesenchymal stromal cells
miR-26a-5p
CDK6
Ischemia–reperfusion injury
Online Access:https://doi.org/10.1186/s10020-021-00324-0

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