Design of Novel Benzimidazole Derivatives as Potential α-amylase Inhibitors by 3D-QSAR Modeling and Molecular Docking Studies

Design of Novel Benzimidazole Derivatives as Potential α-amylase Inhibitors by 3D-QSAR Modeling and Molecular Docking Studies

The α-amylase is an enzyme of a highly conserved glycoside hydrolase family, α-amylase inhibitors can be used as clinical agents for the treatment of Diabetes Mellitus (DM). A 3D-QSAR study was performed on 45 2-aryl benzimidazole derivatives, which have been identified as insulin-independent antidia...

Full description

Bibliographic Details
Main Authors: Khalil EL KHATABİ, İlham AANOUZ, Reda EL-MERNİSSİ, Ayoub KHALDAN, Mohammed Aziz AJANA, Mohammed BOUACHRINE, Tahar LAKHLIFI
Format: Article
Language:English
Published: Turkish Chemical Society 2020-06-01
Series:Journal of the Turkish Chemical Society, Section A: Chemistry
Subjects:
3d-qsar
molecular modeling
computational study
benzimidazole
α-amylase inhibitors
Online Access:https://dergipark.org.tr/tr/pub/jotcsa/issue/52506/703026

Internet

https://dergipark.org.tr/tr/pub/jotcsa/issue/52506/703026

Similar Items