Guanylate cyclase-C/cGMP: an emerging pathway in the regulation of visceral pain

Guanylate cyclase-C/cGMP: an emerging pathway in the regulation of visceral pain

Activation of guanylate cyclase-C (GC-C) expressed predominantly on intestinal epithelial cells by guanylin, uroguanylin or the closely related GC-C agonist peptide, linaclotide, stimulates generation and release of cyclic guanosine-3’,5’-monophosphate (cGMP). Evidence that the visceral analgesic e...

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Bibliographic Details
Main Authors: Gerhard eHannig, Boris eTchernychev, Caroline B Kurtz, Alexander P Bryant, Mark G Currie, Inmaculada eSilos-Santiago
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Abdominal Pain
uroguanylin
cyclic guanosine monophosphate
colonic nociceptor
guanylate cyclase-C
irritable bowel syndrome with constipation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2014.00031/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2014.00031/full

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