Immunomodulatory Potential of the Polysaccharide-Rich Extract from Edible Cyanobacterium Nostoc commune

A dry sample of Nostoc commune from an organic farm in Pingtung city (Taiwan) was used to prepare polysaccharide-rich (NCPS) extract. The conditioned medium (CM) from NCPS-treated human peripheral blood (PB)-mononuclear cells (MNC) effectively inhibited the growth of human leukemic U937 cells and tr...

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Main Authors:	Hui-Fen Liao, Tai-Jung Wu, Jia-Liang Tai, Meng-Chun Chi, Long-Liu Lin
Format:	Article
Language:	English
Published:	MDPI AG 2015-11-01
Series:	Medical Sciences
Subjects:	Nostoc commune polysaccharide-rich extract immunomoduration macrophages leukemia
Online Access:	http://www.mdpi.com/2076-3271/3/4/112

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spelling	doaj-6397e017d8044be184d28ce8ed6c0df52020-11-24T22:44:20ZengMDPI AGMedical Sciences2076-32712015-11-013411212310.3390/medsci3040112medsci3040112Immunomodulatory Potential of the Polysaccharide-Rich Extract from Edible Cyanobacterium Nostoc communeHui-Fen Liao0Tai-Jung Wu1Jia-Liang Tai2Meng-Chun Chi3Long-Liu Lin4Department of Biochemical Science and Technology, National Chiayi University, 300 Syuefu Road, Chiayi City 60004, TaiwanDepartment of Biochemical Science and Technology, National Chiayi University, 300 Syuefu Road, Chiayi City 60004, TaiwanSung Yu Technology Co., Ltd., 7 Dali Road, Rende District, Tainan City 71754, TaiwanDepartment of Applied Chemistry, National Chiayi University, 300 Syuefu Road, Chiayi City 60004, TaiwanDepartment of Applied Chemistry, National Chiayi University, 300 Syuefu Road, Chiayi City 60004, TaiwanA dry sample of Nostoc commune from an organic farm in Pingtung city (Taiwan) was used to prepare polysaccharide-rich (NCPS) extract. The conditioned medium (CM) from NCPS-treated human peripheral blood (PB)-mononuclear cells (MNC) effectively inhibited the growth of human leukemic U937 cells and triggered differentiation of U937 monoblast cells into monocytic/macrophagic lines. Cytokine levels in MNC-CMs showed upregulation of granulocyte/macrophage-colony stimulatory factor and IL-1β and downregulation of IL-6 and IL-17 upon treatment with NCPS. Moreover, murine macrophage RAW264.7 cells treated with NCPS exhibited the stimulatory effects of nitric oxide and superoxide secretion, indicating that NCPS might activate the immunity of macrophages. Collectively, the present study demonstrates that NCPS from N. commune could be potentially used for macrophage activation and consequently inhibited the leukemic cell growth and induced monocytic/macrophagic differentiation.http://www.mdpi.com/2076-3271/3/4/112Nostoc communepolysaccharide-rich extractimmunomodurationmacrophagesleukemia
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Hui-Fen Liao Tai-Jung Wu Jia-Liang Tai Meng-Chun Chi Long-Liu Lin
spellingShingle	Hui-Fen Liao Tai-Jung Wu Jia-Liang Tai Meng-Chun Chi Long-Liu Lin Immunomodulatory Potential of the Polysaccharide-Rich Extract from Edible Cyanobacterium Nostoc commune Medical Sciences Nostoc commune polysaccharide-rich extract immunomoduration macrophages leukemia
author_facet	Hui-Fen Liao Tai-Jung Wu Jia-Liang Tai Meng-Chun Chi Long-Liu Lin
author_sort	Hui-Fen Liao
title	Immunomodulatory Potential of the Polysaccharide-Rich Extract from Edible Cyanobacterium Nostoc commune
title_short	Immunomodulatory Potential of the Polysaccharide-Rich Extract from Edible Cyanobacterium Nostoc commune
title_full	Immunomodulatory Potential of the Polysaccharide-Rich Extract from Edible Cyanobacterium Nostoc commune
title_fullStr	Immunomodulatory Potential of the Polysaccharide-Rich Extract from Edible Cyanobacterium Nostoc commune
title_full_unstemmed	Immunomodulatory Potential of the Polysaccharide-Rich Extract from Edible Cyanobacterium Nostoc commune
title_sort	immunomodulatory potential of the polysaccharide-rich extract from edible cyanobacterium nostoc commune
publisher	MDPI AG
series	Medical Sciences
issn	2076-3271
publishDate	2015-11-01
description	A dry sample of Nostoc commune from an organic farm in Pingtung city (Taiwan) was used to prepare polysaccharide-rich (NCPS) extract. The conditioned medium (CM) from NCPS-treated human peripheral blood (PB)-mononuclear cells (MNC) effectively inhibited the growth of human leukemic U937 cells and triggered differentiation of U937 monoblast cells into monocytic/macrophagic lines. Cytokine levels in MNC-CMs showed upregulation of granulocyte/macrophage-colony stimulatory factor and IL-1β and downregulation of IL-6 and IL-17 upon treatment with NCPS. Moreover, murine macrophage RAW264.7 cells treated with NCPS exhibited the stimulatory effects of nitric oxide and superoxide secretion, indicating that NCPS might activate the immunity of macrophages. Collectively, the present study demonstrates that NCPS from N. commune could be potentially used for macrophage activation and consequently inhibited the leukemic cell growth and induced monocytic/macrophagic differentiation.
topic	Nostoc commune polysaccharide-rich extract immunomoduration macrophages leukemia
url	http://www.mdpi.com/2076-3271/3/4/112
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Immunomodulatory Potential of the Polysaccharide-Rich Extract from Edible Cyanobacterium Nostoc commune

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