ApoE2-associated hypertriglyceridemia is ameliorated by increased levels of apoA-V but unaffected by apoC-III deficiency*

ApoE2-associated hypertriglyceridemia is ameliorated by increased levels of apoA-V but unaffected by apoC-III deficiency*

Apolipoprotein E2 (apoE2)-associated hyperlipidemia is characterized by a disturbed clearance of apoE2-enriched VLDL remnants. Because excess apoE2 inhibits LPL-mediated triglyceride (TG) hydrolysis in vitro, we investigated whether direct or indirect stimulation of LPL activity in vivo reduces the...

Full description

Bibliographic Details
Main Authors:	Gery Gerritsen, Caroline C. van der Hoogt, Frank G. Schaap, Peter J. Voshol, Kyriakos E. Kypreos, Nobuyo Maeda, Albert K. Groen, Louis M. Havekes, Patrick C.N. Rensen, Ko Willems van Dijk
Format:	Article
Language:	English
Published:	Elsevier 2008-05-01
Series:	Journal of Lipid Research
Subjects:	apolipoprotein E2 apolipoprotein A-V apolipoprotein C-III APOE2-knockin mice lipoprotein lipase-mediated very low density lipoprotein-triglyceride hydrolysis adenovirus-mediated gene transfer
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227520425921

Similar Items

ApoC-III deficiency prevents hyperlipidemia induced by apoE overexpression
by: Gery Gerritsen, et al.
Published: (2005-07-01)

Evidence for a complex relationship between apoA-V and apoC-III in patients with severe hypertriglyceridemia
by: Frank G. Schaap, et al.
Published: (2006-10-01)

Severe hypertriglyceridemia in human APOC1 transgenic mice is caused by apoC-I-induced inhibition of LPL
by: Jimmy F.P. Berbée, et al.
Published: (2005-02-01)

Effects of apoA-V on HDL and VLDL metabolism in APOC3 transgenic mice1
by: Shen Qu, et al.
Published: (2007-07-01)

LDL receptor deficiency or apoE mutations prevent remnant clearance and induce hypertriglyceridemia in mices⃞
by: Kyriakos E. Kypreos, et al.
Published: (2006-03-01)

Endogenous apoC-I increases hyperlipidemia in apoE-knockout mice by stimulating VLDL production and inhibiting LPL
by: Marit Westerterp, et al.
Published: (2006-06-01)

ApoA-IV modulates the secretory trafficking of apoB and the size of triglyceride-rich lipoproteins
by: Richard B. Weinberg, et al.
Published: (2012-04-01)

Regulation of macrophage apoE secretion and sterol efflux by the LDL receptor
by: Danijela Lucic, et al.
Published: (2007-02-01)

Current and Emerging Reconstituted HDL-apoA-I and HDL-apoE Approaches to Treat Atherosclerosis
by: Eftaxia-Konstantina Valanti, et al.
Published: (2018-10-01)

Endothelial lipase is less effective at influencing HDL metabolism in vivo in mice expressing apoA-II
by: Uli C. Broedl, et al.
Published: (2006-10-01)

Plasma turnover of HDL apoC-I, apoC-III, and apoE in humans
by: Jeffrey S. Cohn, et al.
Published: (2003-10-01)

Anti-inflammatory apoA-I-mimetic peptides bind oxidized lipids with much higher affinity than human apoA-I*
by: Brian J. Van Lenten, et al.
Published: (2008-11-01)

Antisense inhibition of apoB synthesis with mipomersen reduces plasma apoC-III and apoC-III-containing lipoproteins
by: Jeremy D. Furtado, et al.
Published: (2012-04-01)

ApoC-III ASO promotes tissue LPL activity in the absence of apoE-mediated TRL clearance
by: Bastian Ramms, et al.
Published: (2019-08-01)

New genetic variants in the apoA-I and apoC-III genes and familial combined hyperlipidemia
by: Martine Groenendijk, et al.
Published: (2001-02-01)

ApoE genotype affects allele-specific apo[a] levels for large apo[a] sizes in African Americans: the Harlem-Basset Studys⃞
by: Erdembileg Anuurad, et al.
Published: (2007-03-01)

Dietary fat modulation of apoA-II metabolism and prevention of senile amyloidosis in the senescence- accelerated mouse
by: Makiko Umezawa, et al.
Published: (2003-04-01)

Abnormal in vivo metabolism of apoB-containing lipoproteins in human apoE deficiency
by: Katsunori Ikewaki, et al.
Published: (2004-07-01)

Intestine may be a major site of action for the apoA-I mimetic peptide 4F whether administered subcutaneously or orally[S]
by: Mohamad Navab, et al.
Published: (2011-06-01)

Identification of ApoA4 as a sphingosine 1-phosphate chaperone in ApoM- and albumin-deficient mice
by: Hideru Obinata, et al.
Published: (2019-11-01)

ApoE knockout and knockin mice: the history of their contribution to the understanding of atherogenesis
by: Godfrey S. Getz, et al.
Published: (2016-05-01)

Use of Intralipid for kinetic analysis of HDL apoC-III: evidence for a homogeneous kinetic pool of apoC-III in plasma
by: Minh N. Nguyen, et al.
Published: (2006-06-01)

Quality control in the apoA-I secretory pathway
by: Shaila Bhat, et al.
Published: (2004-07-01)

Characterization of apoM in normal and genetically modified mice
by: Kirsten Faber, et al.
Published: (2004-07-01)

Hyperlipidemia in APOE2 transgenic mice is ameliorated by a truncated apoE variant lacking the C-terminal domain
by: Gery Gerritsen, et al.
Published: (2003-02-01)

Hypertriglyceridemia and cardiovascular risk: a cautionary note about metabolic confounding
by: Allan D. Sniderman, et al.
Published: (2018-01-01)

Secretion of apoB- and apoA-I-containing lipoproteins by chick kidney
by: Patrizia Tarugi, et al.
Published: (1998-04-01)

ApoC-III content of apoB-containing lipoproteins is associated with binding to the vascular proteoglycan biglycan
by: Katherine Olin-Lewis, et al.
Published: (2002-11-01)

Paraoxonase-1 and serum concentrations of HDL-cholesterol and apoA-I
by: Marie-Claude Blatter Garin, et al.
Published: (2006-03-01)

Influence of apoA-I and apoE on the formation of serum amyloid A-containing lipoproteins in vivo and in vitro
by: Veneracion G. Cabana, et al.
Published: (2004-02-01)

ApoA-I cleaved by transthyretin has reduced ability to promote cholesterol efflux and increased amyloidogenicity
by: Márcia Almeida Liz, et al.
Published: (2007-11-01)

Heterozygous mutation of ataxia-telangiectasia mutated gene aggravates hypercholesterolemia in apoE-deficient mice
by: DongFang Wu, et al.
Published: (2005-07-01)

The plasma concentration of HDL-associated apoM is influenced by LDL receptor-mediated clearance of apoB-containing particles
by: Christina Christoffersen, et al.
Published: (2012-10-01)

Model class A and class L peptides increase the production of apoA-I-containing lipoproteins in HepG2 cells
by: Nassrin Dashti, et al.
Published: (2004-10-01)

The roles of apo(a) size, phenotype, and dominance pattern in PCSK9-inhibition-induced reduction in Lp(a) with alirocumab[S]
by: Byambaa Enkhmaa, et al.
Published: (2017-10-01)

ApoB-containing lipoproteins in apoE-deficient mice are not metabolized by the class B scavenger receptor BI
by: Nancy R. Webb, et al.
Published: (2004-02-01)

Increased methionine sulfoxide content of apoA-I in type 1 diabetes
by: Jonathan W.C. Brock, et al.
Published: (2008-04-01)

Active plasma phospholipid transfer protein is associated with apoA-I- but not apoE-containing lipoproteins
by: Marian C. Cheung, et al.
Published: (2006-06-01)

Macrophage-derived apoESendai suppresses atherosclerosis while causing lipoprotein glomerulopathy in hyperlipidemic mice[S]
by: Hagai Tavori, et al.
Published: (2014-10-01)

APOE in the normal brain
by: Sarah A. Flowers, et al.
Published: (2020-03-01)