Using Persistent Homology as a New Approach for Super-Resolution Localization Microscopy Data Analysis and Classification of γH2AX Foci/Clusters

Using Persistent Homology as a New Approach for Super-Resolution Localization Microscopy Data Analysis and Classification of γH2AX Foci/Clusters

DNA double strand breaks (DSB) are the most severe damages in chromatin induced by ionizing radiation. In response to such environmentally determined stress situations, cells have developed repair mechanisms. Although many investigations have contributed to a detailed understanding of repair process...

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Bibliographic Details
Main Authors: Andreas Hofmann, Matthias Krufczik, Dieter W. Heermann, Michael Hausmann
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:International Journal of Molecular Sciences
Subjects:
single-molecule localization microscopy
DNA double strand breaks
γH2AX formation
persistent homology
topology
similarity measure
foci/cluster classification relative to heterochromatin
Online Access:http://www.mdpi.com/1422-0067/19/8/2263

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