Identification of parental line specific effects of MLF2 on resistance to coccidiosis in chickens

• Main Authors: Hong Yeong Ho, Kim Eui-Soo, Lillehoj Hyun S
• Format: Article
• Language: English
• Published: BMC 2011-06-01
• Series: BMC Proceedings

<p>Abstract</p> <p>Background</p> <p><it>MLF2</it> was the candidate gene associated with coccidiosis resistance in chickens. Although single marker analysis supported the association between <it>MLF2</it> and coccidiosis resistance, causative mutation relevant to coccidiosis was not identified yet. Thus, this study suggested segregation analysis of <it>MLF2</it> haplotype and the association test of the other candidate genes using improved data transformation.</p> <p>Results</p> <p>A haplotype probably originated from one parental line was found out of 4 major haplotypes of <it>MLF2</it>. Frequency of this haplotype was 0.2 in parental chickens and its offspring in 12 families. Allele substitution effect of the <it>MLF2</it> haplotype originated from a specific line was associated with increased body weight and fecal egg count explaining coccidiosis resistance. Nevertheless Box-Cox transformation was able to improve normality; association test did not produce obvious different results compared with analysis with log transformed phenotype.</p> <p>Conclusion</p> <p>Allele substitution effect analysis and classification of <it>MLF2</it> haplotype identified the segregation of haplotype associated with coccidiosis resistance. The haplotype originated from a specific parental line was associated with improving disease resistance. Estimating effect of <it>MLF2</it> haplotype on coccidiosis resistance will provide useful information for selecting animals or lines for future study.</p>