Assessing the public health impact of tolerance-based therapies with mathematical models.

Disease tolerance is a defense strategy against infections that aims at maintaining host health even at high pathogen replication or load. Tolerance mechanisms are currently intensively studied with the long-term goal of exploiting them therapeutically. Because tolerance-based treatment imposes less...

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Bibliographic Details
Main Authors: Nathanaël Hozé, Sebastian Bonhoeffer, Roland Regoes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-05-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC5955582?pdf=render