Effect of radical gastrectomy for stress and immune function in patients with cardiac cancer

• Main Authors: Zheng Wang, Zhi-Ming Tan, Zhi-Liang Yang
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2018-09-01
• Series: Journal of Hainan Medical University
• Subjects: Laparoscopic surgery; Cardiac cancer; Stress; Immune function
• Online Access: http://www.hnykdxxb.com/PDF/201818/14.pdf

Objective: To investigate the effects of abdominal and transthoracic surgery on perioperative stress and immune function in patients with cardiac cancer. Methods: 60 patients with cardiac cancer treated in our hospital from May 2016 to October 2017 were collected. According to the different surgical methods, they were divided into the transthoracic group and the abdominal group, with 30 cases in each group. The changes of inflammatory factors, T-lymphocyte subsets, NK cells, immune globulin, and oxidative stress parameters were compared between the two groups before and 7 d after surgery. Result: There were no significant differences in preoperative inflammatory factors, T lymphocyte subsets, NK cells, immunoglobulins, and oxidative stress between the two groups. At 7 d after surgery, COR and CRP levels increased in both groups, but COR and CRP levels in abdominal group were (63.03±5.31) mg/ L and (245.15±22.88) ng/L which were lower than those in transthoracic group. The levels of CD4+,CD4+/CD8+and CD8+ and NK were significantly increased in both groups after operation, and CD4+ and CD4+/CD8+ were (34.23±3.42)% and (1.22±0.12), which were higher than those in the transabdominal group. While the number of CD8+ and NK cells in the group was (28.12±2.91)% and (19.11±1.92)% respectively, which were lower than those in the transthoracic group. The levels of IgA, IgG, and IgM were significantly reduced in both groups after operation, and IgA, IgG, and IgM were (2.84±0.27) g/L, (12.11±1.20) g/L, and (1.46±0.15) g/L respectively, which were higher than those in the transabdominal group. MDA levels in both groups were increased, while SOD levels in both groups were decreased. However, the MDA in the abdominal group was (5.27±0.53) mmol/mL wiche were lower than that in the transthoracic group, and the SOD was (80.26±8.06) U/mL which wewe higher than that in the transthoracic group. Conclusion: The radical gastrectomy can reduce inflammatory stress and oxidative stress in patients with cardiac cancer and protect immune function.