Mechanism of Th17/Treg immune axis regulating the intestinal microflora of ulcerative colitis
Ulcerative colitis (UC) is a type of chronic inflammatory recurrent disease. At present, the etiology and pathogenesis are still unclear, and immune factors are usually considered to be the final link in the pathogenesis of UC. Due to the increasing incidence of this disease, longer course of dis...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Editorial Board of Journal of Hainan Medical University
2021-04-01
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| Series: | Journal of Hainan Medical University |
| Subjects: | |
| Online Access: | http://www.hnykdxxb.com/PDF/202107/12.pdf |
| Summary: | Ulcerative colitis (UC) is a type of chronic inflammatory recurrent disease. At present, the
etiology and pathogenesis are still unclear, and immune factors are usually considered to
be the final link in the pathogenesis of UC. Due to the increasing incidence of this disease,
longer course of disease, and difficult to heal, related research has gradually deepened, and
related researches on intestinal flora, immunity, genetics, etc. have become hotspots. A large
amount of evidence indicates that regulatory T cells (Treg), helper T cell 17 (Th17), Th17/
Treg immune axis and intestinal microbiota in UC patients play an important role in regulating
the occurrence and development of diseases. In recent years, the intestine has been gradually
discovered There is also a certain correlation between the tract microbiota and the Th17/
Treg immune axis. Therefore, this article examines a large number of relevant Chinese and
English materials at home and abroad in recent years to analyze the Th17/Treg cells, intestinal
microbiota and the relationship between the two in UC patients. The existing relevance and
other issues are briefly discussed and summarized in order to provide more practical basis for
clinical targeted therapy. |
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| ISSN: | 1007-1237 1007-1237 |