Modulation of Insulin Sensitivity of Hepatocytes by the Pharmacological Downregulation of Phospholipase D
Background. The role of phospholipase D (PLD) as a positive modulator of glucose uptake activation by insulin in muscle and adipose cells has been demonstrated. The role of PLD in the regulation of glucose metabolism by insulin in the primary hepatocytes has been determined in this study. Methods. F...
Main Authors: | Nataliya A. Babenko, Vitalina S. Kharchenko |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2015-01-01
|
Series: | International Journal of Endocrinology |
Online Access: | http://dx.doi.org/10.1155/2015/794838 |
Similar Items
-
Thyroxine signal transduction in liver cells involves phospholipase C and phospholipase D activation. Genomic independent action of thyroid hormone
by: Krasilnikova Oksana A, et al.
Published: (2001-04-01) -
Secretory phospholipase A2 group IIA modulates insulin sensitivity and metabolism
by: Michael S. Kuefner, et al.
Published: (2017-09-01) -
Pharmacological modulation of ATP-sensitive potassium channels in an insulin-secreting cell-line
by: Kozlowski, Roland Zbigniew
Published: (1990) -
TNF-α Downregulation Modifies Insulin Receptor Substrate 1 (IRS-1) in Metabolic Signaling of Diabetic Insulin-Resistant Hepatocytes
by: Iraj Alipourfard, et al.
Published: (2019-01-01) -
Group III phospholipase A2 downregulation attenuated survival and metastasis in ovarian cancer and promotes chemo-sensitization
by: Upasana Ray, et al.
Published: (2021-06-01)