Effect of tumor necrosis factor-α on the expression of the ammonia transporter Rhcg in the brain in mice with acute liver failure

Effect of tumor necrosis factor-α on the expression of the ammonia transporter Rhcg in the brain in mice with acute liver failure

Abstract Background Ammonia and tumor necrosis factor-alpha (TNF-α) play important roles in the mechanisms of hepatic encephalopathy (HE). Rhesus glycoprotein C (Rhcg) is important for ammonia transport especially in the kidney. The aim of the present study was to investigate the role of Rhcg in the...

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Bibliographic Details
Main Authors: Wen Wang, Hui Lu, Xu Lu, Donglei Wang, Zhaohan Wang, Wenying Dai, Jinyong Wang, Pei Liu
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Journal of Neuroinflammation
Subjects:
Acute liver failure
Hepatic encephalopathy
Ammonia transporters
Tumor necrosis factor-alpha
Blood brain barrier
Online Access:http://link.springer.com/article/10.1186/s12974-018-1264-8

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