E3 Ubiquitin Ligase APC/C<sup>Cdh1</sup> Regulation of Phenylalanine Hydroxylase Stability and Function

E3 Ubiquitin Ligase APC/C<sup>Cdh1</sup> Regulation of Phenylalanine Hydroxylase Stability and Function

Phenylketonuria (PKU) is an autosomal recessive metabolic disorder caused by the dysfunction of the enzyme phenylalanine hydroxylase (PAH). Alterations in the level of PAH leads to the toxic accumulation of phenylalanine in the blood and brain. Protein degradation mediated by ubiquitination is a pri...

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Bibliographic Details
Main Authors: Apoorvi Tyagi, Neha Sarodaya, Kamini Kaushal, Arun Pandian Chandrasekaran, Ainsley Mike Antao, Bharathi Suresh, Byung Ho Rhie, Kye-Seong Kim, Suresh Ramakrishna
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
enzyme assay
hyperphenylalaninemia
liver cancer
neurological damage
tetrahydrobiopterin
ubiquitin-proteasome system
Online Access:https://www.mdpi.com/1422-0067/21/23/9076

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https://www.mdpi.com/1422-0067/21/23/9076

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