Prognostic significance of cell cycle-associated proteins p16, pRB, cyclin D1 and p53 in resected oropharyngeal carcinoma

Prognostic significance of cell cycle-associated proteins p16, pRB, cyclin D1 and p53 in resected oropharyngeal carcinoma

Abstract Background Human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) has an improved outcome and may allow for treatment de-escalation. High-risk HPV (HR-HPV) infection is associated with deregulated expression of the cell cycle-associated proteins p16INK4, pRB, cycli...

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Bibliographic Details
Main Authors: Michaela Plath, Martina A. Broglie, Diana Förbs, Sandro J. Stoeckli, Wolfram Jochum
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Journal of Otolaryngology - Head and Neck Surgery
Subjects:
Oropharyngeal squamous cell carcinoma
Human papillomavirus
p16
Retinoblastoma protein
Cyclin D1
p53
Online Access:http://link.springer.com/article/10.1186/s40463-018-0298-3

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