Differentiating between near- and non-cognate codons in Saccharomyces cerevisiae.

Differentiating between near- and non-cognate codons in Saccharomyces cerevisiae.

Decoding of mRNAs is performed by aminoacyl tRNAs (aa-tRNAs). This process is highly accurate, however, at low frequencies (10(-3) - 10(-4)) the wrong aa-tRNA can be selected, leading to incorporation of aberrant amino acids. Although our understanding of what constitutes the correct or cognate aa-t...

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Bibliographic Details
Main Authors: Ewan P Plant, Phuc Nguyen, Jonathan R Russ, Yvette R Pittman, Thai Nguyen, Jack T Quesinberry, Terri Goss Kinzy, Jonathan D Dinman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC1885216?pdf=render

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