Growth Hormone Upregulates Mediators of Melanoma Drug Efflux and Epithelial-to- Mesenchymal Transition In Vitro and In Vivo

Growth Hormone Upregulates Mediators of Melanoma Drug Efflux and Epithelial-to- Mesenchymal Transition In Vitro and In Vivo

Growth hormone (GH) and the GH receptor (GHR) are expressed in a wide range of malignant tumors including melanoma. However, the effect of GH/insulin-like growth factor (IGF) on melanoma in vivo has not yet been elucidated. Here we assessed the physical and molecular effects of GH on mouse melanoma...

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Bibliographic Details
Main Authors: Yanrong Qian, Reetobrata Basu, Samuel C. Mathes, Nathan A. Arnett, Silvana Duran-Ortiz, Kevin R. Funk, Alison L. Brittain, Prateek Kulkarni, Joseph C. Terry, Emily Davis, Jordyn T. Singerman, Brooke E. Henry, Edward O. List, Darlene E. Berryman, John J. Kopchick
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Cancers
Subjects:
growth hormone
growth hormone receptor
insulin-like growth factor-1
melanoma
multidrug efflux pumps
epithelial-to-mesenchymal transition
Online Access:https://www.mdpi.com/2072-6694/12/12/3640

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