3D-printed devices for continuous-flow organic chemistry

• Main Authors: Vincenza Dragone, Victor Sans, Mali H. Rosnes, Philip J. Kitson, Leroy Cronin
• Format: Article
• Language: English
• Published: Beilstein-Institut 2013-05-01
• Series: Beilstein Journal of Organic Chemistry
• Subjects: 3D printing; flow chemistry; flow IR; in-line analysis; imine reduction; imine synthesis; millifluidics; reactionware
• Online Access: https://doi.org/10.3762/bjoc.9.109

We present a study in which the versatility of 3D-printing is combined with the processing advantages of flow chemistry for the synthesis of organic compounds. Robust and inexpensive 3D-printed reactionware devices are easily connected using standard fittings resulting in complex, custom-made flow systems, including multiple reactors in a series with in-line, real-time analysis using an ATR-IR flow cell. As a proof of concept, we utilized two types of organic reactions, imine syntheses and imine reductions, to show how different reactor configurations and substrates give different products.