Perioperative Management of Type 2N Von Willebrand’s Disease with Recombinant Factor VIII in a Patient Undergoing Knee-Replacement Surgery

Perioperative Management of Type 2N Von Willebrand’s Disease with Recombinant Factor VIII in a Patient Undergoing Knee-Replacement Surgery

Type 2N Von Willebrand's disease (2N VWD) is a rare, recessively inherited bleeding disorder, comprising 1-2% of all VWD patients, usually manifesting as a mild bleeding diathesis. Treatment includes desmopressin (DDAVP) or intermediate purity plasma-derived FVIII concentrates containing residu...

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Main Authors: Srivasavi Dukka, David John Allsup
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Case Reports in Hematology
Online Access:http://dx.doi.org/10.1155/2013/837906
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spelling doaj-63264998002040b082ea7f5873becd142020-11-25T01:12:58ZengHindawi LimitedCase Reports in Hematology2090-65602090-65792013-01-01201310.1155/2013/837906837906Perioperative Management of Type 2N Von Willebrand’s Disease with Recombinant Factor VIII in a Patient Undergoing Knee-Replacement SurgerySrivasavi Dukka0David John Allsup1Department of Haematology, Queen's Centre for Oncology and Haematology, Castle Hill Hospital, Castle Road, Cottingham, East Riding of Yorkshire HU16 5JQ, UKDepartment of Haematology, Queen's Centre for Oncology and Haematology, Castle Hill Hospital, Castle Road, Cottingham, East Riding of Yorkshire HU16 5JQ, UKType 2N Von Willebrand's disease (2N VWD) is a rare, recessively inherited bleeding disorder, comprising 1-2% of all VWD patients, usually manifesting as a mild bleeding diathesis. Treatment includes desmopressin (DDAVP) or intermediate purity plasma-derived FVIII concentrates containing residual VWF. We present a case of a 75-year-old gentleman, incidentally diagnosed with type 2N VWD in 2002 on routine blood testing before surgery with an ISTH bleeding score of 1-2, who was treated with recombinant FVIII preoperatively.http://dx.doi.org/10.1155/2013/837906
collection DOAJ
language English
format Article
sources DOAJ
author Srivasavi Dukka
David John Allsup
spellingShingle Srivasavi Dukka
David John Allsup
Perioperative Management of Type 2N Von Willebrand’s Disease with Recombinant Factor VIII in a Patient Undergoing Knee-Replacement Surgery
Case Reports in Hematology
author_facet Srivasavi Dukka
David John Allsup
author_sort Srivasavi Dukka
title Perioperative Management of Type 2N Von Willebrand’s Disease with Recombinant Factor VIII in a Patient Undergoing Knee-Replacement Surgery
title_short Perioperative Management of Type 2N Von Willebrand’s Disease with Recombinant Factor VIII in a Patient Undergoing Knee-Replacement Surgery
title_full Perioperative Management of Type 2N Von Willebrand’s Disease with Recombinant Factor VIII in a Patient Undergoing Knee-Replacement Surgery
title_fullStr Perioperative Management of Type 2N Von Willebrand’s Disease with Recombinant Factor VIII in a Patient Undergoing Knee-Replacement Surgery
title_full_unstemmed Perioperative Management of Type 2N Von Willebrand’s Disease with Recombinant Factor VIII in a Patient Undergoing Knee-Replacement Surgery
title_sort perioperative management of type 2n von willebrand’s disease with recombinant factor viii in a patient undergoing knee-replacement surgery
publisher Hindawi Limited
series Case Reports in Hematology
issn 2090-6560
2090-6579
publishDate 2013-01-01
description Type 2N Von Willebrand's disease (2N VWD) is a rare, recessively inherited bleeding disorder, comprising 1-2% of all VWD patients, usually manifesting as a mild bleeding diathesis. Treatment includes desmopressin (DDAVP) or intermediate purity plasma-derived FVIII concentrates containing residual VWF. We present a case of a 75-year-old gentleman, incidentally diagnosed with type 2N VWD in 2002 on routine blood testing before surgery with an ISTH bleeding score of 1-2, who was treated with recombinant FVIII preoperatively.
url http://dx.doi.org/10.1155/2013/837906
work_keys_str_mv AT srivasavidukka perioperativemanagementoftype2nvonwillebrandsdiseasewithrecombinantfactorviiiinapatientundergoingkneereplacementsurgery
AT davidjohnallsup perioperativemanagementoftype2nvonwillebrandsdiseasewithrecombinantfactorviiiinapatientundergoingkneereplacementsurgery
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